| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-02-27 |
| タイトル |
|
|
タイトル |
A challenging case of giant atypical fibroxanthoma on non-chronically sun-damaged skin: a case report with TP53 somatic mutation (c.375+1 G>A) |
|
言語 |
en |
| 著者 |
Zorlu, Özge
Karabağ, Sevil
Aşıkovalı, Semih
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| アクセス権 |
|
|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
|
言語 |
en |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
atypical fibroxanthoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
pleomorphic dermal sarcoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
recurrence |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
histopathology |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
TP53 somatic mutation |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Atypical fibroxanthoma (AFX) is a rare tumor of uncertain histogenetic origin, generally seen in elderly patients’ chronically sun-damaged skin, most frequently in the head and neck region. Due to the absence of specific histopathologic features, AFX is a diagnosis of exclusion. Herein, we report clinical, histopathological, and molecular features of a young patient with a recurrent and giant AFX lesion on non-chronically sun-damaged skin. Histologically, the tumor was well-circumscribed, encapsulated, and dermal-based, composed of highly atypical and pleomorphic bizarre spindled cells with hyperchromatic and irregular nuclei and scarce multinucleated giant cells. There was no subcutaneous invasion, necrosis, or perineural/perivascular invasion. Tumoral cells were diffusely and strongly positive for CD10 but negative for melanocytic, cytokeratin, and muscle immunohistochemical markers. Almost five years after the excision, no recurrence and/or distant metastasis was observed. A pathogenic variant of a TP53 somatic mutation (c.375+1 G>A) was identified in the tumor. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.88.1.162 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/874.html |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 88,
号 1,
p. 162-169,
発行日 2026-02
|
15_Zorlu.pdf (65.1 MB)
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