| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-03-02 |
| タイトル |
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|
タイトル |
Hierarchical wrinkle pattern drives tenogenic differentiation from human mesenchymal stem cells |
|
言語 |
en |
| 著者 |
Kim, Jeonghyun
Nagashima, So
Wang, Junfeng
Matsubara, Seishiro
Maeda, Eijiro
Okumura, Dai
Matsumoto, Takeo
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| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
Jeonghyun Kim, So Nagashima, Junfeng Wang, Seishiro Matsubara, Eijiro Maeda, Dai Okumura, Takeo Matsumoto, Hierarchical wrinkle pattern drives tenogenic differentiation from human mesenchymal stem cells, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine (239(10)) pp. 1000-1009. Copyright © [2025] (IMechE). DOI: [10.1177/09544119251378949]. |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Stem cells possess the unique abilities to self-renew and differentiate into various cell types, making them invaluable in tissue engineering and regenerative medicine. This study explores the behavior of human bone marrow-derived mesenchymal stem cells (hMSCs) on poly(dimethylsiloxane) (PDMS) substrates with hierarchical wrinkle patterns. These bio-inspired patterns were created using the surface instability of gold-coated elastomer bilayers. The results indicate that the hierarchical wrinkles not only promote cell alignment but also up-regulate tenogenic differentiation markers without chemical induction. The cells exhibited increased expression of tenocyte markers (Mkx, and Col1) and decreased expression of osteoblast (Alp, and Opn) and chondrocyte (Sox9) markers. This bio-inspired substrate design, mimicking natural extracellular matrix structures, provides a promising approach for developing functional tissue constructs and advancing stem cell-based regenerative therapies. The study underscores the importance of substrate topography in directing stem cell fate, highlighting its potential in mechanobiological applications and tissue engineering. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
SAGE Publications |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1177/09544119251378949 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0954-4119 |
| 書誌情報 |
en : Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
巻 239,
号 10,
p. 1000-1009,
発行日 2025-10
|
Manuscript_WrinkleJ_v9_2_unmarked.pdf (1.5 MB)
