| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-03-03 |
| タイトル |
|
|
タイトル |
Urinary Presepsin as a Biomarker for Inflammatory-Cell Infiltration in Kidney Diseases |
|
言語 |
en |
| 著者 |
Kawazoe, Tomohiro
Tanaka, Akihito
Furuhashi, Kazuhiro
Kato, Noritoshi
Kosugi, Tomoki
Maruyama, Shoichi
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利 |
|
|
権利情報 |
"This is a non-final version of an article published in final form in (Kawazoe, Tomohiro; Tanaka, Akihito; Furuhashi, Kazuhiro; Kato, Noritoshi; Kosugi, Tomoki; Maruyama, Shoichi. Urinary Presepsin as a Biomarker for Inflammatory-Cell Infiltration in Kidney Diseases: SA-PO0933. Journal of the American Society of Nephrology 36(10S):10.1681/ASN.20252a9jbxx5, October 2025. DOI: 10.1681/ASN.20252a9jbxx5)." |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Kidney biopsy has long been the gold standard for diagnosing renal diseases. However, bleeding complications can disturb timely diagnosis. In clinical practice, there is an unmet need for diagnostic tools that can serve as alternatives to, or supplements for, kidney biopsy. Plasma presepsin (PSEP) is a well-known biomarker for early detection of sepsis. It is the N-terminal fragment of soluble CD14, which is expressed on granulocytes and monocytes and released into the bloodstream through phagocytosis. We hypothesized that urinary PSEP (uPSEP) may increase in renal inflammatory conditions. Methods: This analytical cross-sectional study included patients registered in the Nagoya Kidney Disease Registry in 2020 and 2022. PSEP levels were measured using urine samples collected and cryopreserved at the time of kidney biopsy. Patients were classified according to biopsy-proven diagnoses and the association with uPSEP was evaluated. In addition, we assessed the association between uPSEP and the degree of inflammatory cell infiltration in the interstitium, graded as minimal (<5%), mild (5–25%), moderate (26–50%), or severe (>50%). Results: A total of 543 patients (241 females and 302 males) with a median age of 59 years at the time of biopsy (IQR, 43–72 years) were included. The log-transformed uPSEP/creatinine (Cr) levels were compared among major renal diagnoses. Patients with tubulointerstitial nephritis (TIN) showed significantly higher levels compared to those with focal segmental glomerulosclerosis, IgA nephropathy, minimal change nephrotic syndrome, and membranous nephropathy. ROC analysis using uPSEP/Cr to detect TIN yielded the area under the curve (AUC) of 0.802 (95%CI, 0.741–0.862), with a cutoff value of 1526 ng/gCr. The AUC of uPSEP/Cr was significantly higher than that of urinary N-acetyl-β-D-glucosaminidase (NAG)/Cr (0.772 vs 0.491; P<0.001). When adjusted for confounding factors, the odds ratio for TIN-diagnosis per 1000-ng/gCr increase in uPSEP was 1.13 (95% CI, 1.02–1.25; P=0.0246). uPSEP/Cr levels were also significantly elevated in cases with more severe interstitial infiltration, with a significant trend confirmed by the Jonckheere-Terpstra test (P<0.001). Conclusion: Urinary presepsin is a promising biomarker for detecting inflammatory cell infiltration in kidney. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wolters Kluwer Health |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1681/ASN.20252a9jbxx5 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1046-6673 |
| 書誌情報 |
en : Journal of the American Society of Nephrology
巻 36,
号 10S,
p. 10.1681/ASN.20252a9jbxx5,
発行日 2025-10
|
| ファイル公開日 |
|
|
日付 |
2026-10-01 |
|
日付タイプ |
Available |
abstract_2025ASN.pdf (17 KB)
