| アイテムタイプ |
itemtype_ver1(1) |
| 公開日 |
2026-04-07 |
| タイトル |
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タイトル |
Persistence Pays: Diagnosing Tuberculous Meningitis after 11 Negative Polymerase Chain Reaction Evaluations |
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言語 |
en |
| 著者 |
Obara, Kazuki
Tsuboi, Takashi
Mori, Yu
Sanda, Akihiro
Mouri, Naohiro
Takagi, Shinnosuke
Aoki, Shinichiro
Katsuno, Masahisa
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
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|
権利情報 |
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Managing tuberculous meningitis (TBM) is challenging because of its poor prognosis and the difficulty in making an early diagnosis due to the low sensitivity of cerebrospinal fluid (CSF) polymerase chain reaction (PCR) evaluations. A 75-year-old woman presented with fatigue and multiple enlarged lymph nodes and was initially suspected of having metastatic cancer of unknown primary origin. Differential diagnoses included carcinomatous meningitis, neurosarcoidosis, and TBM, as suggested by the presence of multiple enhancing cerebral nodules. Despite 11 negative PCR evaluations, including nested PCR of CSF and biopsied lymph nodes within the first 3 days of empirical anti-tubercular treatment, TBM was eventually confirmed by CSF cultures 32 days later. This case highlights the need for repeated sampling. |
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言語 |
en |
| 出版者 |
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出版者 |
The Japanese Society of Internal Medicine |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.2169/internalmedicine.4087-24 |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0918-2918 |
| 書誌情報 |
en : Internal Medicine
巻 64,
号 6,
p. 931-936,
発行日 2025-03-15
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Obara_et_al_2025_InternMed.pdf (453 KB)
