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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats

http://hdl.handle.net/2237/23011
http://hdl.handle.net/2237/23011
ff15ceb1-2cdc-41e8-9791-d1317655f344
名前 / ファイル ライセンス アクション
k8878_thesis.pdf k8878_thesis.pdf (5.7 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2015-09-17
タイトル
タイトル Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats
言語 en
著者 Hori, Kiyomi

× Hori, Kiyomi

WEKO 60507

en Hori, Kiyomi

Search repository
Ozaki, Noriyuki

× Ozaki, Noriyuki

WEKO 60508

en Ozaki, Noriyuki

Search repository
Suzuki, Shigeyuki

× Suzuki, Shigeyuki

WEKO 60509

en Suzuki, Shigeyuki

Search repository
Sugiura, Yasuo

× Sugiura, Yasuo

WEKO 60510

en Sugiura, Yasuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Cisplatin
キーワード
主題Scheme Other
主題 TRPV1
キーワード
主題Scheme Other
主題 TRPV2
キーワード
主題Scheme Other
主題 P2X3
キーワード
主題Scheme Other
主題 ASIC3
キーワード
主題Scheme Other
主題 Hyperalgesia
抄録
内容記述 The role of ion channels expressed in sensory neurons on mechanical and thermal hyperalgesia was examined in a rat model of cisplatin-induced peripheral neuropathy. The rats were injected with 3 mg/kg of cisplatin intraperitoneally once per week for five consecutive weeks. The von Frey test, pin-prick test and plantar test were performed to examine any noxious sensitivity of the skin. The Randall–Selitto test of the gastrocnemius muscle (GM) and the measurement of grip forces were performed to quantify muscle hyperalgesia. Coordination/motor was assessed by Rota-rod testing. Expressions of the ion channels TRPV1, TRPV2, P2X3 and ASIC3 were examined in dorsal root ganglion (DRG) neurons and the muscle afferent neurons innervating GM. Effects of antagonists against either P2X3 or ASICs on behavioral responses were evaluated. Mechanical hyperalgesia and allodynia of both skin and muscle were observed in cisplatin-treated animals. Expressions of TRPV2, P2X3, and ASIC3 increased in all DRG neurons. In addition, expressions of P2X3 and ASIC3 also increased in muscle afferent neurons in DRGs. Antagonists against P2X3,2/3 and ASICs showed a suppressive effect on both skin and muscle hyperalgesia induced by cisplatin administration. Upregulation of TRPV2, P2X3, and ASIC3 may play important roles in the mechanical hyperalgesia induced by cisplatin. Furthermore, cisplatin treatment also induced muscle hyperalgesia in muscle afferent neurons in connection with the upregulation of P2X3 and ASIC3.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成22年4月30日 堀紀代美氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.pain.2010.03.005
ISSN
収録物識別子タイプ PISSN
収録物識別子 0304-3959
書誌情報 PAIN

巻 149, 号 2, p. 393-405, 発行日 2010-04-30
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 2010
学位授与年月日
学位授与年月日 2010-04-30
学位授与番号
学位授与番号 甲第8878号
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/23011
識別子タイプ HDL
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