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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Effects of Collective Histone State Dynamics on Epigenetic Landscape and Kinetics of Cell Reprogramming

http://hdl.handle.net/2237/24584
http://hdl.handle.net/2237/24584
adf832ea-1307-49e5-8b1c-6f8b40f55029
名前 / ファイル ライセンス アクション
SciRep2015Ashwin.pdf SciRep2015Ashwin.pdf (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-05
タイトル
タイトル Effects of Collective Histone State Dynamics on Epigenetic Landscape and Kinetics of Cell Reprogramming
言語 en
著者 Ashwin, S. S.

× Ashwin, S. S.

WEKO 66464

en Ashwin, S. S.

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 66465

en Sasai, Masaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
抄録
内容記述 Cell reprogramming is a process of transitions from differentiated to pluripotent cell states via transient intermediate states. Within the epigenetic landscape framework, such a process is regarded as a sequence of transitions among basins on the landscape; therefore, theoretical construction of a model landscape which exhibits experimentally consistent dynamics can provide clues to understanding epigenetic mechanism of reprogramming. We propose a minimal gene-network model of the landscape, in which each gene is regulated by an integrated mechanism of transcription-factor binding/unbinding and the collective chemical modification of histones. We show that the slow collective variation of many histones around each gene locus alters topology of the landscape and significantly affects transition dynamics between basins. Differentiation and reprogramming follow different transition pathways on the calculated landscape, which should be verified experimentally via single-cell pursuit of the reprogramming process. Effects of modulation in collective histone state kinetics on transition dynamics and pathway are examined in search for an efficient protocol of reprogramming.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep16746
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
書誌情報 en : Scientific Reports

巻 5, p. 16746-16746, 発行日 2015-11
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.1038/srep16746
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/24584
識別子タイプ HDL
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