@article{oai:nagoya.repo.nii.ac.jp:00022645, author = {SHIMADA, ATSUSHI}, issue = {2}, journal = {Nagoya Journal of Medical Science}, month = {Dec}, note = {Studies on blood coagulation were performed in the patients with hematopoietic disorders. Two hundred and twenty-three patients were investigated, consisting of 100 cases of leukemia, 36 of aplastic anemia, 7 of iron deficiency anemia and 80 of primary hemorrhagic diseases. The last consisted of 15 cases of purpura simplex, 32 of idiopathic thrombocytopenic purpura, 25 of hemophilia A and 8 of hemophilia B.\ In each hemorrhagic disease there were found some differences among the characterisitic features of coagulation defects and also between hemorrhagic and non-hemorrhagic states.\ In general platelet counts ranging from 30,000/cu. mm to 60,000/cu. mm could be considered to be the critical zone for manifesting hemorrhages in leukemia, aplastic anemia and idiopathic thrombocytopenic purpura. Functions of platelets were disturbed in some hemorrhagic diseases, and life span of platelets was shorten in many hematopoietic diseases. In studies on fibrinolysis there were noted increased activity of fibrinolysis in many cases, but no significant relationship was observed between increase of various factors of fibrinolytic activity and hemorrhagic manifestions.\ There were performed analysis of the etiological factors that were classified into 5 elements of the blood vessel, platelet, clotting factors, anticoagulants and fibrinolysis. The combined abnormality of more than three elements were frequently seen in the bleeding states, than in the non-bleeding cases.}, pages = {119--128}, title = {Blood Coagulation Studies of Various Hematological Disorders}, volume = {29}, year = {1966} }