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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 78(3)

Nogo receptor 1 is expressed in both primary cultured glial cells and neurons

https://doi.org/10.18999/nagjms.78.3.303
https://doi.org/10.18999/nagjms.78.3.303
e62f0b5b-8078-40da-b81b-1497f9688ccf
名前 / ファイル ライセンス アクション
18_Ukai.pdf 18_Ukai.pdf (14.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-09-12
タイトル
タイトル Nogo receptor 1 is expressed in both primary cultured glial cells and neurons
著者 Ukai, Junichi

× Ukai, Junichi

WEKO 66743

Ukai, Junichi

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Imagama, Shiro

× Imagama, Shiro

WEKO 66744

Imagama, Shiro

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Ohgomori, Tomohiro

× Ohgomori, Tomohiro

WEKO 66745

Ohgomori, Tomohiro

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Ito, Zenya

× Ito, Zenya

WEKO 66746

Ito, Zenya

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Ando, Kei

× Ando, Kei

WEKO 66747

Ando, Kei

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 66748

Ishiguro, Naoki

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 66749

Kadomatsu, Kenji

Search repository
キーワード
主題Scheme Other
主題 NgR1
キーワード
主題Scheme Other
主題 Spinal cord injury
キーワード
主題Scheme Other
主題 astrocytes
抄録
内容記述 Nogo receptor (NgR) is common in myelin-derived molecules, i.e., Nogo, MAG, and OMgp, and plays important roles in both axon fasciculation and the inhibition of axonal regeneration. In contrast to NgR’s roles in neurons, its roles in glial cells have been poorly explored. Here, we found a dynamic regulation of NgR1 expression during development and neuronal injury. NgR1 mRNA was consistently expressed in the brain from embryonic day 18 to postnatal day 25. In contrast, its expression significantly decreased in the spinal cord during development. Primary cultured neurons, microglia, and astrocytes expressed NgR1. Interestingly, a contusion injury in the spinal cord led to elevated NgR1 mRNA expression at the injury site, but not in the motor cortex, 14 days after injury. Consistent with this, astrocyte activation by TGFb1 increased NgR1 expression, while microglia activation rather decreased NgR1 expression. These results collectively suggest that NgR1 expression is enhanced in a milieu of neural injury. Our findings may provide insight into the roles of NgR1 in glial cells.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.78.3.303
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 78, 号 3, p. 303-311, 発行日 2016-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/783.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/24816
識別子タイプ HDL
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