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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 28(1)

Histological and Electron Microscopic Investigation of the Liver in the Choline Deficient Guinea Pig

https://doi.org/10.18999/nagjms.28.1.81
https://doi.org/10.18999/nagjms.28.1.81
c59d0b85-3bcd-4bba-b227-52e942d7fc3b
名前 / ファイル ライセンス アクション
v28n1p81_100.pdf v28n1p81_100.pdf (5.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-09-26
タイトル
タイトル Histological and Electron Microscopic Investigation of the Liver in the Choline Deficient Guinea Pig
著者 ASAI, JUNPEI

× ASAI, JUNPEI

WEKO 93826

ASAI, JUNPEI

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抄録
内容記述 Young guinea pigs fed a choline deficient diet were employed for light and electron microscopic studies. They showed severe growth retardation, muscular weakness, diarrhea and subcutaneous hemorrhage. About 73% of the deaths occurred within 5 weeks and survival time varied from 8 to 305 days. The symptoms of animals died within 5 weeks were more acute than the remainders. The gross appearance of the dead animals was characterized by marked emaciation, disappearance of the adipose tissue and congestion of the liver. Fat deposition in the liver was found microscopically in 17 of 48 animals. The light microscopic examination revealed definite degenerative changes of the liver cells including vacuolation, swelling and necrosis, and these findings became prominent with the duration of choline deficiency. In the electron microscopic examination the most conspicuous changes occurred in mitochondria of the liver cell. Mitochondria decreased in number gradually as choline deficiency progressed and manifested some characteristic features at each period of the experiment. Two types of mitochondrial swelling could be observed, the first type was recognized at the early stage and the second type developed at the terminal stage after the 10th week of choline deficiency. In the first type, mitochondria became balloon-like but there was no essential destruction of its fundamental membranous structures. In the second type, mitochondria became gigantic and membranous structures were more or less distracted. Occasionally there found protrusion of mitochondria, dissolution of mitochondrial membrane, disarrangemenet of cristae and appearance of small vesicles in mitochondrial matrix at the terminal stage of choline deficiency. On the other hand, the animals of the recovery experiment showed notable improvements on the above-mentioned symptoms and changes of the liver.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.28.1.81
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/281/281.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 28, 号 1, p. 81-100, 発行日 1965-12
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