{"created":"2021-03-01T06:30:30.425555+00:00","id":22719,"links":{},"metadata":{"_buckets":{"deposit":"67d41461-d061-4122-a655-b5bdb93ba996"},"_deposit":{"created_by":17,"id":"22719","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"22719"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00022719","sets":["499:508:509:1901"]},"author_link":["93867"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1966-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"195","bibliographicPageStart":"179","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The therapeutic aspects of hemophilia were studied on a total of 22 cases, consisting of 13 hemophilia A, 8 hemophilia B and one with congenital combined deficiency of Factor V and Factor VIII. 1) The half life of the activity of Factor VIII following intravenous injection of fresh plasma, estimated 7 times in 4 cases, was ranged from 4 to 11 hours. Besides such short half life of Factor VIII, there appeared some cases with acquired resistance to transfusion efficacy after frequently repeated transfusions of blood or its preparation. Therefore blood transfusion should be avoided except when absolutely necessary. 2) Prednisolone and betamethasone were found to possess striking clinical efficacy in all of 9 cases with hemophilia, that was revealed by decrease in frequency of hemorrhage and by accelerated absorption of blood from hemorrhagic foci. But there found no case at all where activity of congenitally deficient clotting factor increased following their administration. 3) Antiplasmic substances, ε-ACA and trans-AMCHA, were also found to have such striking clinical efficacy as corticosteroids. In 15 out of 17 cases with hemophilia were found the decrease in frequency of hemorrhage, and the decrease of pain accompanying hemorrhage in all of 17 cases. Following the administration of antiplasmic substances in these hemophiliacs, the fibrinolytic activity of circulating blood and the inhibitor for formation of intrinsic thromboplastin were decreased, but in no case the activity of congenitally deficient clotting factor increased. Based on the above results, it is concluded that antiplasmic substances and corticosteroids can be used extremely satisfactorily in the inhibition of hemorrhage in hemophilia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.28.3-4.179","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/2834/2834.html","subitem_relation_type_select":"URI"}}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATSUMI, OTOHEI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"93867","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-22"}],"displaytype":"detail","filename":"v28n34p179_195.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"v28n34p179_195.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/22719/files/v28n34p179_195.pdf"},"version_id":"2a2d4a0d-df69-4846-b20c-e5106da8a3e2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"New Aspects on the Treatment of Hemophilia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"New Aspects on the Treatment of Hemophilia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1901"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-09-27"},"publish_date":"2016-09-27","publish_status":"0","recid":"22719","relation_version_is_last":true,"title":["New Aspects on the Treatment of Hemophilia"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T04:45:29.840198+00:00"}