@article{oai:nagoya.repo.nii.ac.jp:00022720,
 author = {KATSUMI, OTOHEI},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Jun},
 note = {In order to elucidate the factors which account for hemorrhagic diathesis of hemophilia, hemostatic studies were carried out in 55 hemophiliacs, consisting of 39 of hemophilia A and 16 of hemophilia B. These patients were classified into severe group (18 cases), moderate group (25 cases) and minimum group (12 cases), according to clinical severity without regard to the data of coagulation test. The results were summarized as follows; 1) The clinical severity in hemophilia did not necessarily coincide with data of coagulation test. Moreover, when hemostatic tests were conducted for pro- longed period on severe cases fluctuations were seen in their hemorrhagic manifestations, but, during same observational period, there showed no variations in the grade of the amount of their congenitally deficient clotting factor. 2) On the other hand, changes in fibrinolytic activity of these hemophiliacs had a definite relationship not only with the grade of clinical severity but also the fluctuations of hemorrhagic manifestation.Based on the above results, it became clear that the hemorrhagic disorders seen in hemophilia can be influenced by fluctuation in the fibrinolytic system.},
 pages = {196--203},
 title = {On Hemostatic Studies in Hemophilia},
 volume = {28},
 year = {1966}
}