@article{oai:nagoya.repo.nii.ac.jp:00022723,
 author = {IMAI, MASAO},
 issue = {3-4},
 journal = {Nagoya Journal of Medical Science},
 month = {Jun},
 note = {This paper deals with electron microscopic changes in the acinar cells of the pancreas after the injection of antibiotics. Chloramphenicol and tetracycline therapeutic doses 25 mg/kg body weight/day respectively were administrated to guinea pigs for 10 or 20 days and the two same overdoses 250 mg/kg body weight/ day for 5 days. Pancreozymin 3 units/kg body weight was administered singly or combined with chloramphenicol therapeutic dose and overdose. The changes found in these series with special emphasis upon zymogen granules, rough-surfaced endoplasmic reticulum, mitochondria and Golgi complex were compared. The two antibiotics therapeutic dose series show some slight but not significant changes- in relation to rough·surfaced endoplasmic reticulum- in the acinar cells. The two antibiotics therapeutic dose series show some slight but not significant changes-in relation to rough·surfaced endoplasmic reticulum-in the acinar cells. The two overdose series reveal different serious changes-a marked decrease in number and vacuolisation of zymogen granules, and a decrease in number of intracisternal granules and vesiculation of rough-surfaced endoplasmic reticulum, large vacuoles surrounded by mitochondria or by a single mitochondrion-like structure occur. The Golgi complex is somewhat dilated. Pancreozymin singly induced accelerated secretion of zymogen granules and increase of dense material in the Golgi complex and intracisternal granules in the rough-surfaced endoplasmic reticulum, but pancreozymin combined with over dosed chloramphenicol does not turn the rough-surfaced endoplasmic reticulum disturbed. By comparing these changes found in the different series, the role and significance of the organellae in the acinar cells are discussed in relation to secretion of the pancreas and enzymatic protein synthesis.},
 pages = {247--260},
 title = {Ultrastructural Changes of Pancreatic Acinar Cells Following Antibiotics Administration. Experiments of Guinea Pigs with Chloramphenicol and Tetracycline},
 volume = {28},
 year = {1966}
}