{"created":"2021-03-01T06:30:30.882526+00:00","id":22726,"links":{},"metadata":{"_buckets":{"deposit":"baae5be1-8ee3-4d1e-a300-f450637ea04e"},"_deposit":{"id":"22726","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22726"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00022726","sets":["336:695:696"]},"author_link":["66892","66893","66894","66895","66896","66897","66898","66899","66900","66901"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1817","bibliographicPageStart":"1803","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"MOLECULAR AND CELLULAR BIOLOGY","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"pVHL, the protein product of the von Hippel-Lindau (VHL) tumor suppressor gene, is a ubiquitin ligase that targets hypoxia-inducible factor α (HIF-α) for proteasomal degradation. Although HIF-α activation is necessary for VHL disease pathogenesis, constitutive activation of HIF-α alone did not induce renal clear cell carcinomas and pheochromocytomas in mice, suggesting the involvement of an HIF-α-independent pathway in VHL pathogenesis. Here, we show that the transcription factor B-Myb is a pVHL substrate that is degraded via the ubiquitin-proteasome pathway and that vascular endothelial growth factor (VEGF)- and/or platelet-derived growth factor (PDGF)-dependent tyrosine 15 phosphorylation of B-Myb prevents its degradation. Mice injected with B-Myb knockdown 786-O cells developed dramatically larger tumors than those bearing control cell tumors. Microarray screening of B-Myb-regulated genes showed that the expression of HIF-α-dependent genes was not affected by B-Myb knockdown, indicating that B-Myb prevents HIF-α-dependent tumorigenesis through an HIF-α-independent pathway. These data indicate that the regulation of B-Myb by pVHL plays a critical role in VHL disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1128/MCB.00067-16"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/24879"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1128/MCB.00067-16","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0270-7306","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okumura, Fumihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uematsu, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Byrne, Stuart D.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Mie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Joo-Okumura, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikimi, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shuin, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukui, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakatsukasa, Kunio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamura, Takumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"66901","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-22"}],"displaytype":"detail","filename":"Mol_Cell_Biol_2016-Okumura-1803-17.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Mol_Cell_Biol_2016-Okumura-1803-17.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/22726/files/Mol_Cell_Biol_2016-Okumura-1803-17.pdf"},"version_id":"73cab4d5-3074-4523-99c8-9ccf8861fae6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["696"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-09-27"},"publish_date":"2016-09-27","publish_status":"0","recid":"22726","relation_version_is_last":true,"title":["Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:12:14.202362+00:00"}