@article{oai:nagoya.repo.nii.ac.jp:00022732, author = {NAGASAKA, TETSUO and ANDO, SHIGERU and TAKAGI, KENTARO}, issue = {1}, journal = {Nagoya Journal of Medical Science}, month = {Nov}, note = {This study is a part of the work which has been done in purpose of investigating the effects of a long term exposure to a lowered barometric pressure in the 1965-1966 Nagoya university scientific and mountaineering expedition to the Andes. Changes in breath holding time, Po2 and Pco2, of the expired air at the breaking point and alveolar Po2 and Pco2, pulmonary ventilation and respiratory frequency were measured in the 14 male subjects during the 22 days of sojourn at an altitude of 4200 m. Breath holding time and Pco2 of the expired air at the breaking point and alveolar Pco2 became increasingly lower during the two weeks of sojourn. After the 2nd week the breath holding time, Pco2 level at the break- ing point reached the minimum while the alveolar Pco2 continued to fall. Pulmonary ventilation and respiratory frequency as well as the alveolar Pco2 increased and reached a ceiling during the third week of sojourn. Those rather quick changes during the first two weeks would indicate an increased sensitivity of the respiratory center to CO2 stimulus, but the discrepancy between the change in breath holding time and that in alveolar Pco2 after the third week of sojourn was difficult to be interpreted in this paper.}, pages = {85--91}, title = {Breath Holding during the Three Weeks of Sojourn at High Altitude}, volume = {29}, year = {1966} }