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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Simple resection of truncal desmoid tumors: A case series

http://hdl.handle.net/2237/25081
http://hdl.handle.net/2237/25081
68b0183b-cce2-4c42-843f-c418409fb2e1
名前 / ファイル ライセンス アクション
ol_12_2_1564_PDF.pdf ol_12_2_1564_PDF.pdf ファイル公開:2017/02/01 (923.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-11-22
タイトル
タイトル Simple resection of truncal desmoid tumors: A case series
言語 en
著者 Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 67392

en Nishida, Yoshihiro

Search repository
Tsukushi, Satoshi

× Tsukushi, Satoshi

WEKO 67393

en Tsukushi, Satoshi

Search repository
Urakawa, Hiroshi

× Urakawa, Hiroshi

WEKO 67394

en Urakawa, Hiroshi

Search repository
Hamada, Shunsuke

× Hamada, Shunsuke

WEKO 67395

en Hamada, Shunsuke

Search repository
Kozawa, Eiji

× Kozawa, Eiji

WEKO 67396

en Kozawa, Eiji

Search repository
Ikuta, Kunihiro

× Ikuta, Kunihiro

WEKO 67397

en Ikuta, Kunihiro

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 67398

en Ishiguro, Naoki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 Desmoid tumors of the extra-abdominal and abdominal wall have been associated with morbidity due to the aggressive nature of the surgery and high recurrence rates. Surgery that does not cause functional impairment is desired for patients with desmoid tumors. In the present study, among patients with desmoid tumors who were prospectively and consecutively treated with identical conservative treatment with meloxicam, a selected patients of patients were treated with less invasive surgery than wide-resection. Out of 60 patients pathologically diagnosed with desmoid tumors, 9 patients with tumors refractory to conservative treatment and 4 patients who refused to receive this type of treatment were treated with planned simple resection. Subsequently, the clinical outcome of the patients and the mutational status of the catenin β‑1 (CTNNB1) gene in the tumors were analyzed. The mean age of the 13 patients that underwent planned simple resection was 39 years, and the tumors were located in the abdominal wall in 6 cases, the chest wall in 4 cases and the neck in 3 cases. All excised specimens were evaluated and positive microscopic margins were identified; however, during the mean follow‑up period of 30 months, 12/13 cases, 7 of which had T41A mutations and 5 of which had no mutations (wild‑type), did not develop recurrence. Only 1 initial case with an S45F mutation in the CTNNB1 gene developed recurrence. The results of the present prospectively treated with simple resection and retrospectively analyzed study suggest that planned simple resection could serve as a therapeutic modality for extraperitoneal desmoid tumors, particularly truncal ones with a wild-type or T41A mutational status.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3892/ol.2016.4792
ISSN
収録物識別子タイプ PISSN
収録物識別子 1792-1074
書誌情報 en : Oncology Letters

巻 12, 号 2, p. 1564-1568, 発行日 2016-08
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.3892/ol.2016.4792
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25081
識別子タイプ HDL
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