{"created":"2021-03-01T06:30:46.627723+00:00","id":22965,"links":{},"metadata":{"_buckets":{"deposit":"1ec3b539-2e53-4ce5-8803-465783897dc9"},"_deposit":{"id":"22965","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22965"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00022965","sets":["320:321:322"]},"author_link":["67772","67773","67774","67775"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1148","bibliographicPageStart":"1141","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"Bioscience, Biotechnology, and Biochemistry","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Siglecs recognize the sialic acid moiety and regulate various immune responses. In the present study, we compared the expression levels of Siglecs in human monocytes and macrophages using a quantitative real-time reverse transcription–polymerase chain reaction analysis. The differentiation of monocytes into macrophages by macrophage colony-stimulating factor or granulocyte macrophage colony-stimulating factor enhanced the expression of Siglec-7 and Siglec-9. The differentiated macrophages were stimulated by lipopolysaccharide (LPS) plus interferon (IFN)-γ or interleukin (IL)-4. The expression of Siglec-10 was enhanced by IL-4, whereas that of Siglec-7 was reduced by LPS plus IFN-γ. The expression of Siglec-9 was not affected by these stimuli. The knockdown of Siglec-9 enhanced the expression of CCR7 induced by the LPS or the LPS plus IFN-γ stimulation, and decreased the IL-4-induced expression of CD200R. These results suggest that Siglec-9 is one of the main Siglecs in human blood monocytes/macrophages and modulates innate immunity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1080/09168451.2016.1146070"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/25146"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09168451.2016.1146070","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c)日本農芸化学会. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 29/02/2016, available online: http://www.tandfonline.com/10.1080/09168451.2016.1146070.","subitem_rights_language":"ja"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-8451","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higuchi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"67772","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoji, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"67773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iijima, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"67774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishijima, Ken-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"67775","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-03-01"}],"displaytype":"detail","filename":"Higuchi_et_al.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Higuchi_et_al.pdf ファイル公開：2017/03/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/22965/files/Higuchi_et_al.pdf"},"version_id":"9fa0c85f-c66c-4beb-995b-b6f441a9078f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human","subitem_subject_scheme":"Other"},{"subitem_subject":"lectin","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophages","subitem_subject_scheme":"Other"},{"subitem_subject":"sialic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"Siglec","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["322"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-12-05"},"publish_date":"2016-12-05","publish_status":"0","recid":"22965","relation_version_is_last":true,"title":["Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:11:36.953213+00:00"}