{"_buckets": {"deposit": "3782194c-8917-43d5-9d7c-14c3352e21d8"}, "_deposit": {"id": "22985", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22985"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00022985", "sets": ["501"]}, "author_link": ["67885", "67886", "67887", "67888", "67889"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "192", "bibliographicPageStart": "183", "bibliographicVolumeNumber": "66", "bibliographic_titles": [{"bibliographic_title": "PATHOLOGY INTERNATIONAL", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Clinical pathologists have long been aware that in many types of human malignant tumors, the cells are often connected and form groups of various sizes or “nests”. In this way, they achieve “collective invasion” into the surrounding stroma, rather than spreading out individually. Such collective behavior is also a common feature of migration during embryonic and postnatal developmental stages, suggesting there are advantages gained by collective cell migration in the organisms. Recent studies have revealed the mechanisms underlying the collective invasion of cancer cells. These mechanisms differ from those observed in the migration of single cells in culture, including reliance on the epithelial–mesenchymal transition program. Whereas intercellular adhesion appears to be coordinated, cancer cell groups can be heterogenous, including cells that are leaders and those that are followers. There is also interaction with the tumor microenvironment that is a prerequisite for collective invasion of cancer. In this review, we describe recently emerging mechanisms underlying the collective migration of cells, with a particular focus in our studies on the actin-binding protein Girdin/GIV and the transcriptional regulator tripartite motif containing 27. These studies provide new perspectives on the mechanistic analogy between cancer and development.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1111/pin.12391"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/25169"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/pin.12391", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Wang, X., Enomoto, A., Asai, N., Kato, T., and Takahashi, M. (2016) Collective invasion of cancer: Perspectives from pathology and development. Pathology International, 66: 183–192], which has been published in final form at [http://doi.org/10.1111/pin.12391]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1320-5463", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Wang, Xiaoze", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "67885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Enomoto, Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "67886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asai, Naoya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "67887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "67888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Masahide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "67889", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-04-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Wang_et_al_Pathol_Int_2016.pdf", "filesize": [{"value": "29.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 29500000.0, "url": {"label": "Wang_et_al_Pathol_Int_2016.pdf ファイル公開：2017/04/04", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/22985/files/Wang_et_al_Pathol_Int_2016.pdf"}, "version_id": "31c449f3-2c0e-49e2-84df-23e944139e87"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "collective migration", "subitem_subject_scheme": "Other"}, {"subitem_subject": "collective invasion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neuroblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leading cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Girdin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MRTF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Trim27", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Collective invasion of cancer: Perspectives from pathology and development", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Collective invasion of cancer: Perspectives from pathology and development", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/25169", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2016-12-08"}, "publish_date": "2016-12-08", "publish_status": "0", "recid": "22985", "relation": {}, "relation_version_is_last": true, "title": ["Collective invasion of cancer: Perspectives from pathology and development"], "weko_shared_id": -1}