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Collective invasion of cancer: Perspectives from pathology and development
http://hdl.handle.net/2237/25169
http://hdl.handle.net/2237/25169e4bcda17-0151-4251-b0fc-5a78e3cfdef0
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-12-08 | |||||
タイトル | ||||||
タイトル | Collective invasion of cancer: Perspectives from pathology and development | |||||
言語 | en | |||||
著者 |
Wang, Xiaoze
× Wang, Xiaoze× Enomoto, Atsushi× Asai, Naoya× Kato, Takuya× Takahashi, Masahide |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [Wang, X., Enomoto, A., Asai, N., Kato, T., and Takahashi, M. (2016) Collective invasion of cancer: Perspectives from pathology and development. Pathology International, 66: 183–192], which has been published in final form at [http://doi.org/10.1111/pin.12391]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collective migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | collective invasion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuroblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | leading cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Girdin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MRTF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Trim27 | |||||
抄録 | ||||||
内容記述 | Clinical pathologists have long been aware that in many types of human malignant tumors, the cells are often connected and form groups of various sizes or “nests”. In this way, they achieve “collective invasion” into the surrounding stroma, rather than spreading out individually. Such collective behavior is also a common feature of migration during embryonic and postnatal developmental stages, suggesting there are advantages gained by collective cell migration in the organisms. Recent studies have revealed the mechanisms underlying the collective invasion of cancer cells. These mechanisms differ from those observed in the migration of single cells in culture, including reliance on the epithelial–mesenchymal transition program. Whereas intercellular adhesion appears to be coordinated, cancer cell groups can be heterogenous, including cells that are leaders and those that are followers. There is also interaction with the tumor microenvironment that is a prerequisite for collective invasion of cancer. In this review, we describe recently emerging mechanisms underlying the collective migration of cells, with a particular focus in our studies on the actin-binding protein Girdin/GIV and the transcriptional regulator tripartite motif containing 27. These studies provide new perspectives on the mechanistic analogy between cancer and development. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/pin.12391 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1320-5463 | |||||
書誌情報 |
en : PATHOLOGY INTERNATIONAL 巻 66, 号 4, p. 183-192, 発行日 2016-04 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1111/pin.12391 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25169 | |||||
識別子タイプ | HDL |