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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Collective invasion of cancer: Perspectives from pathology and development

http://hdl.handle.net/2237/25169
http://hdl.handle.net/2237/25169
e4bcda17-0151-4251-b0fc-5a78e3cfdef0
名前 / ファイル ライセンス アクション
Wang_et_al_Pathol_Int_2016.pdf Wang_et_al_Pathol_Int_2016.pdf ファイル公開:2017/04/04 (29.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-08
タイトル
タイトル Collective invasion of cancer: Perspectives from pathology and development
言語 en
著者 Wang, Xiaoze

× Wang, Xiaoze

WEKO 67885

en Wang, Xiaoze

Search repository
Enomoto, Atsushi

× Enomoto, Atsushi

WEKO 67886

en Enomoto, Atsushi

Search repository
Asai, Naoya

× Asai, Naoya

WEKO 67887

en Asai, Naoya

Search repository
Kato, Takuya

× Kato, Takuya

WEKO 67888

en Kato, Takuya

Search repository
Takahashi, Masahide

× Takahashi, Masahide

WEKO 67889

en Takahashi, Masahide

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Wang, X., Enomoto, A., Asai, N., Kato, T., and Takahashi, M. (2016) Collective invasion of cancer: Perspectives from pathology and development. Pathology International, 66: 183–192], which has been published in final form at [http://doi.org/10.1111/pin.12391]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
キーワード
主題Scheme Other
主題 cancer
キーワード
主題Scheme Other
主題 collective migration
キーワード
主題Scheme Other
主題 collective invasion
キーワード
主題Scheme Other
主題 neuroblast
キーワード
主題Scheme Other
主題 leading cell
キーワード
主題Scheme Other
主題 Girdin
キーワード
主題Scheme Other
主題 MRTF
キーワード
主題Scheme Other
主題 Trim27
抄録
内容記述 Clinical pathologists have long been aware that in many types of human malignant tumors, the cells are often connected and form groups of various sizes or “nests”. In this way, they achieve “collective invasion” into the surrounding stroma, rather than spreading out individually. Such collective behavior is also a common feature of migration during embryonic and postnatal developmental stages, suggesting there are advantages gained by collective cell migration in the organisms. Recent studies have revealed the mechanisms underlying the collective invasion of cancer cells. These mechanisms differ from those observed in the migration of single cells in culture, including reliance on the epithelial–mesenchymal transition program. Whereas intercellular adhesion appears to be coordinated, cancer cell groups can be heterogenous, including cells that are leaders and those that are followers. There is also interaction with the tumor microenvironment that is a prerequisite for collective invasion of cancer. In this review, we describe recently emerging mechanisms underlying the collective migration of cells, with a particular focus in our studies on the actin-binding protein Girdin/GIV and the transcriptional regulator tripartite motif containing 27. These studies provide new perspectives on the mechanistic analogy between cancer and development.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/pin.12391
ISSN
収録物識別子タイプ PISSN
収録物識別子 1320-5463
書誌情報 en : PATHOLOGY INTERNATIONAL

巻 66, 号 4, p. 183-192, 発行日 2016-04
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/pin.12391
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25169
識別子タイプ HDL
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