{"created":"2021-03-01T06:30:51.145978+00:00","id":23033,"links":{},"metadata":{"_buckets":{"deposit":"93740fd5-56c0-4d39-9ca4-72a3bb8baa5e"},"_deposit":{"id":"23033","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23033"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00023033","sets":["499:500:501"]},"author_link":["68096","68097","68098","68099","68100","68101","68102","68103","68104"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1424","bibliographicPageStart":"1416","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Stem Cells Translational Medicine","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic liver injury from various causes often results in liver fibrosis (LF). Although the liver possesses endogenous tissue-repairing activities, these can be overcome by sustained inflammation and excessive fibrotic scar formation. Advanced LF leads to irreversible cirrhosis and subsequent liver failure and/or hepatic cancer. Here, using the mouse carbon tetrachloride (CCl4)-induced LF model, we showed that a single intravenous administration of stem cells derived from human exfoliated deciduous teeth (SHEDs) or of SHED-derived serum-free conditioned medium (SHED-CM) resulted in fibrotic scar resolution. SHED-CM suppressed the gene expression of proinflammatory mediators, such as TNF-α, IL-1β, and iNOS, and eliminated activated hepatic stellate cells by inducing their apoptosis, but protected parenchymal hepatocytes from undergoing apoptosis. In addition, SHED-CM induced tissue-repairing macrophages that expressed high levels of the profibrinolytic factor, matrix metalloproteinase 13. Furthermore, SHED-CM suppressed the CCl4-induced apoptosis of primary cultured hepatocytes. SHED-CM contained a high level of hepatocyte growth factor (HGF). Notably, HGF-depleted SHED-CM (dHGF-CM) did not suppress the proinflammatory response or resolve fibrotic scarring. Furthermore, SHED-CM, but not dHGF-CM, inhibited CCl4-induced hepatocyte apoptosis. These results suggest that HGF plays a central role in the SHED-CM-mediated resolution of LF. Taken together, our findings suggest that SHED-CM provides multifaceted therapeutic benefits for the treatment of LF.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.5966/sctm.2015-0353"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/25222"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AlphaMed Press","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5966/sctm.2015-0353","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©AlphaMed Press. Marina Hirata, Masatoshi Ishigami, Yoshihiro Matsushita, Takanori Ito, Hisashi Hattori, Hideharu Hibi, Hidemi Goto, Minoru Ueda, Akihito Yamamoto; \"Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis\" Stem Cells Trans Med 2016; 5:1416-1424; first published on June 8, 2016; doi:10.5966/sctm.2015-0353","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2157-6564","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirata, Marina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishigami, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsushita, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hattori, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hibi, Hideharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goto, Hidemi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueda, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Akihito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-01"}],"displaytype":"detail","filename":"hirata.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"hirata.pdf ファイル公開：2017/04/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/23033/files/hirata.pdf"},"version_id":"f07163f4-0a4c-463f-a7f6-2e25c43c996b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-12-16"},"publish_date":"2016-12-16","publish_status":"0","recid":"23033","relation_version_is_last":true,"title":["Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T05:05:53.221370+00:00"}