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Self-assembling Peptide Reduces Glial Scarring, Attenuates Posttraumatic Inflammation, and Promotes Neurite Outgrowth of Spinal Motor Neurons
http://hdl.handle.net/2237/25346
http://hdl.handle.net/2237/2534697ab7f8b-eda0-42ff-93f7-19f2f49ec322
名前 / ファイル | ライセンス | アクション |
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Ando_Spine_re.pdf (678.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-13 | |||||
タイトル | ||||||
タイトル | Self-assembling Peptide Reduces Glial Scarring, Attenuates Posttraumatic Inflammation, and Promotes Neurite Outgrowth of Spinal Motor Neurons | |||||
言語 | en | |||||
著者 |
Ando, Kei
× Ando, Kei× Imagama, Shiro× Ito, Zenya× Kobayashi, Kazuyoshi× Hida, Tetsuro× Nakashima, Hiroaki× Ito, Kenyu× Tsushima, Mikito× Ishikawa, Yoshimoto× Matsumoto, Akiyuki× Nishida, Koji× Nishida, Yoshihiro× Ishiguro, Naoki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a non-final version of an article published in final form in (SPINE. v.41, n.20, 2016, p.E1201-E1207). | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fibrous scar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glial scar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neurite outgrowth | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | scaffold | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spinal cord injury | |||||
抄録 | ||||||
内容記述 | Study Design. Self-assembling peptide gel (SPG-178) provides new evidence for the role of a scaffold for treatment of the spinal cord through induction of neuroprotective factors. Objective. To verify the reproducibility of SPG-178 as scaffold after spinal cord injury, we examine the characteristics of SPG-178 and protective effect on neural cells in vitro and in vivo. Summary of Background Data. The central nervous system extracellular matrix may play a role in maintenance of the neuronal network by inhibiting axonal growth and suppressing formation of additional inadequate synapses. In this study, we show increased expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and tropomyosin receptor kinase (TrkA and TrkB) in SPG-178-promoted neurite outgrowth of motor neurons in vitro, and decreased inflammation and glial scar with use of SPG-178 in vivo. Methods. We examined the effect of a self-assembling peptide, SPG-178, as a scaffold for neurite outgrowth of spinal motor neurons in vitro. An in vivo analysis was performed to evaluate if the SPG-178 scaffold attenuated or enhanced expression of various genes after spinal cord injury model rats. Results. Expression of NGF, BDNF, NT-4, TrkA, and TrkB increased in SPG-178-promoted neurite outgrowth of motor neurons in vitro. In vivo, SPG-178 increased expression of glial cell line-derived neurotrophic factor and NGF, and decreased glial scar. Conclusion. This study provides new evidence for the role of SPG-178 as a scaffold in the spinal cord and suggests that this peptide is a neuroprotective factor that may serve as an alternative treatment for neuronal injuries. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wolters Kluwer Health | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1097/BRS.0000000000001611 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0362-2436 | |||||
書誌情報 |
en : SPINE 巻 41, 号 20, p. E1201-E1207, 発行日 2016-10-15 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1097/BRS.0000000000001611 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25346 | |||||
識別子タイプ | HDL |