@article{oai:nagoya.repo.nii.ac.jp:00023208,
 author = {Murata, Takayuki and Noda, Chieko and Narita, Yohei and Watanabe, Takahiro and Yoshida, Masahiro and Ashio, Keiji and Sato, Yoshitaka and Goshima, Fumi and Kanda, Teru and Yoshiyama, Hironori and Tsurumi, Tatsuya and Kimura, Hiroshi},
 issue = {8},
 journal = {Journal of Virology},
 month = {Apr},
 note = {Latent membrane protein 1 (LMP1) is a major oncogene essential for primary B cell transformation by Epstein-Barr virus (EBV). Previous studies suggested that some transcription factors, such as PU.1, RBP-Jκ, NF-κB, and STAT, are involved in this expression, but the underlying mechanism is unclear. Here, we identified binding sites for PAX5, AP-2, and EBF in the proximal LMP1 promoter (ED-L1p). We first confirmed the significance of PU.1 and POU domain transcription factor binding for activation of the promoter in latency III. We then focused on the transcription factors AP-2 and early B cell factor (EBF). Interestingly, among the three AP-2-binding sites in the LMP1 promoter, two motifs were also bound by EBF. Overexpression, knockdown, and mutagenesis in the context of the viral genome indicated that AP-2 plays an important role in LMP1 expression in latency II in epithelial cells. In latency III B cells, on the other hand, the B cell-specific transcription factor EBF binds to the ED-L1p and activates LMP1 transcription from the promoter.},
 pages = {3873--3889},
 title = {Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor},
 volume = {90},
 year = {2016}
}