{"created":"2021-03-01T06:31:02.689757+00:00","id":23208,"links":{},"metadata":{"_buckets":{"deposit":"f9620c46-8acf-403f-986f-718fff9b61d7"},"_deposit":{"id":"23208","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23208"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00023208","sets":["499:500:501"]},"author_link":["68761","68762","68763","68764","68765","68766","68767","68768","68769","68770","68771","68772"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"3889","bibliographicPageStart":"3873","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"Journal of Virology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Latent membrane protein 1 (LMP1) is a major oncogene essential for primary B cell transformation by Epstein-Barr virus (EBV). Previous studies suggested that some transcription factors, such as PU.1, RBP-Jκ, NF-κB, and STAT, are involved in this expression, but the underlying mechanism is unclear. Here, we identified binding sites for PAX5, AP-2, and EBF in the proximal LMP1 promoter (ED-L1p). We first confirmed the significance of PU.1 and POU domain transcription factor binding for activation of the promoter in latency III. We then focused on the transcription factors AP-2 and early B cell factor (EBF). Interestingly, among the three AP-2-binding sites in the LMP1 promoter, two motifs were also bound by EBF. Overexpression, knockdown, and mutagenesis in the context of the viral genome indicated that AP-2 plays an important role in LMP1 expression in latency II in epithelial cells. In latency III B cells, on the other hand, the B cell-specific transcription factor EBF binds to the ED-L1p and activates LMP1 transcription from the promoter.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1128/JVI.03227-15"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/25404"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1128/JVI.03227-15","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-538X","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Murata, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Chieko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68762","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Narita, Yohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68763","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashio, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Yoshitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goshima, Fumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanda, Teru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiyama, Hironori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsurumi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"68772","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-22"}],"displaytype":"detail","filename":"Murata_et_al_Jv2016.pdf","filesize":[{"value":"7.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Murata_et_al_Jv2016.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/23208/files/Murata_et_al_Jv2016.pdf"},"version_id":"b8b9a3ba-62f9-4906-ac61-176d40ededbd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-17"},"publish_date":"2017-01-17","publish_status":"0","recid":"23208","relation_version_is_last":true,"title":["Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T05:06:18.551117+00:00"}