ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "5f2ae087-13c4-4950-a4dc-4fd26752a56b"}, "_deposit": {"id": "23239", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23239"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00023239", "sets": ["501"]}, "author_link": ["68994", "68995", "68996", "68997", "68998", "68999", "69000", "69001", "69002", "69003", "69004", "69005", "69006", "69007", "69008", "69009"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "47", "bibliographicPageEnd": "17102", "bibliographicPageStart": "17091", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "The Journal of Neuroscience", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Chondroitin sulfate (CS) proteoglycans are strong inhibitors of structural rearrangement after injuries of the adult CNS. In addition to CS chains, keratan sulfate (KS) chains are also covalently attached to some proteoglycans. CS and KS sometimes share the same core protein, but exist as independent sugar chains. However, the biological significance of KS remains elusive. Here, we addressed the question of whether KS is involved in plasticity after spinal cord injury. Keratanase II (K-II) specifically degraded KS, i.e., not CS, in vivo. This enzyme digestion promoted the recovery of motor and sensory function after spinal cord injury in rats. Consistent with this, axonal regeneration/sprouting was enhanced in K-II-treated rats. K-II and the CS-degrading enzyme chondroitinase ABC exerted comparable effects in vivo and in vitro. However, these two enzymes worked neither additively nor synergistically. These data and further in vitro studies involving artificial proteoglycans (KS/CS-albumin) and heat-denatured or reduced/alkylated proteoglycans suggested that all three components of the proteoglycan moiety, i.e., the core protein, CS chains, and KS chains, were required for the inhibitory activity of proteoglycans. We conclude that KS is essential for, and has an impact comparable to that of CS on, postinjury plasticity. Our study also established that KS and CS are independent requirements for the proteoglycan-mediated inhibition of axonal regeneration/sprouting.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "https://doi.org/10.1523/JNEUROSCI.5120-10.2011"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/25434"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Society for Neuroscience", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1523/JNEUROSCI.5120-10.2011", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright(c)2011 the authors", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0270-6474", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Imagama, Shiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68994", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, Kazuma", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68995", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tauchi, Ryoji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68996", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinjo, Ryuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68997", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohgomori, Tomohiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68998", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Zenya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "68999", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Haoqian", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69000", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Yoshihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69001", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asami, Nagamasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69002", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshita, Sawako", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69003", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiura, Nobuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69004", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hideto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69005", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Toshihide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiguro, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69007", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuyama, Yukihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69008", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kadomatsu, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69009", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "17091.full.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "17091.full.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/23239/files/17091.full.pdf"}, "version_id": "53e834cc-d056-4259-b191-558576e74549"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/25434", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-01-19"}, "publish_date": "2017-01-19", "publish_status": "0", "recid": "23239", "relation": {}, "relation_version_is_last": true, "title": ["Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury

http://hdl.handle.net/2237/25434
http://hdl.handle.net/2237/25434
0334da7b-eb61-4c66-b69d-3b95583b5bee
名前 / ファイル ライセンス アクション
17091.full.pdf 17091.full.pdf (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-19
タイトル
タイトル Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury
言語 en
著者 Imagama, Shiro

× Imagama, Shiro

WEKO 68994

en Imagama, Shiro

Search repository
Sakamoto, Kazuma

× Sakamoto, Kazuma

WEKO 68995

en Sakamoto, Kazuma

Search repository
Tauchi, Ryoji

× Tauchi, Ryoji

WEKO 68996

en Tauchi, Ryoji

Search repository
Shinjo, Ryuichi

× Shinjo, Ryuichi

WEKO 68997

en Shinjo, Ryuichi

Search repository
Ohgomori, Tomohiro

× Ohgomori, Tomohiro

WEKO 68998

en Ohgomori, Tomohiro

Search repository
Ito, Zenya

× Ito, Zenya

WEKO 68999

en Ito, Zenya

Search repository
Zhang, Haoqian

× Zhang, Haoqian

WEKO 69000

en Zhang, Haoqian

Search repository
Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 69001

en Nishida, Yoshihiro

Search repository
Asami, Nagamasa

× Asami, Nagamasa

WEKO 69002

en Asami, Nagamasa

Search repository
Takeshita, Sawako

× Takeshita, Sawako

WEKO 69003

en Takeshita, Sawako

Search repository
Sugiura, Nobuo

× Sugiura, Nobuo

WEKO 69004

en Sugiura, Nobuo

Search repository
Watanabe, Hideto

× Watanabe, Hideto

WEKO 69005

en Watanabe, Hideto

Search repository
Yamashita, Toshihide

× Yamashita, Toshihide

WEKO 69006

en Yamashita, Toshihide

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 69007

en Ishiguro, Naoki

Search repository
Matsuyama, Yukihiro

× Matsuyama, Yukihiro

WEKO 69008

en Matsuyama, Yukihiro

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 69009

en Kadomatsu, Kenji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Copyright(c)2011 the authors
抄録
内容記述 Chondroitin sulfate (CS) proteoglycans are strong inhibitors of structural rearrangement after injuries of the adult CNS. In addition to CS chains, keratan sulfate (KS) chains are also covalently attached to some proteoglycans. CS and KS sometimes share the same core protein, but exist as independent sugar chains. However, the biological significance of KS remains elusive. Here, we addressed the question of whether KS is involved in plasticity after spinal cord injury. Keratanase II (K-II) specifically degraded KS, i.e., not CS, in vivo. This enzyme digestion promoted the recovery of motor and sensory function after spinal cord injury in rats. Consistent with this, axonal regeneration/sprouting was enhanced in K-II-treated rats. K-II and the CS-degrading enzyme chondroitinase ABC exerted comparable effects in vivo and in vitro. However, these two enzymes worked neither additively nor synergistically. These data and further in vitro studies involving artificial proteoglycans (KS/CS-albumin) and heat-denatured or reduced/alkylated proteoglycans suggested that all three components of the proteoglycan moiety, i.e., the core protein, CS chains, and KS chains, were required for the inhibitory activity of proteoglycans. We conclude that KS is essential for, and has an impact comparable to that of CS on, postinjury plasticity. Our study also established that KS and CS are independent requirements for the proteoglycan-mediated inhibition of axonal regeneration/sprouting.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Society for Neuroscience
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1523/JNEUROSCI.5120-10.2011
ISSN
収録物識別子タイプ PISSN
収録物識別子 0270-6474
書誌情報 en : The Journal of Neuroscience

巻 31, 号 47, p. 17091-17102, 発行日 2011-11
著者版フラグ
値 publisher
URI
識別子 https://doi.org/10.1523/JNEUROSCI.5120-10.2011
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25434
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:38:43.047821
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3