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Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury
http://hdl.handle.net/2237/25434
http://hdl.handle.net/2237/254340334da7b-eb61-4c66-b69d-3b95583b5bee
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-19 | |||||
タイトル | ||||||
タイトル | Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury | |||||
言語 | en | |||||
著者 |
Imagama, Shiro
× Imagama, Shiro× Sakamoto, Kazuma× Tauchi, Ryoji× Shinjo, Ryuichi× Ohgomori, Tomohiro× Ito, Zenya× Zhang, Haoqian× Nishida, Yoshihiro× Asami, Nagamasa× Takeshita, Sawako× Sugiura, Nobuo× Watanabe, Hideto× Yamashita, Toshihide× Ishiguro, Naoki× Matsuyama, Yukihiro× Kadomatsu, Kenji |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright(c)2011 the authors | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chondroitin sulfate (CS) proteoglycans are strong inhibitors of structural rearrangement after injuries of the adult CNS. In addition to CS chains, keratan sulfate (KS) chains are also covalently attached to some proteoglycans. CS and KS sometimes share the same core protein, but exist as independent sugar chains. However, the biological significance of KS remains elusive. Here, we addressed the question of whether KS is involved in plasticity after spinal cord injury. Keratanase II (K-II) specifically degraded KS, i.e., not CS, in vivo. This enzyme digestion promoted the recovery of motor and sensory function after spinal cord injury in rats. Consistent with this, axonal regeneration/sprouting was enhanced in K-II-treated rats. K-II and the CS-degrading enzyme chondroitinase ABC exerted comparable effects in vivo and in vitro. However, these two enzymes worked neither additively nor synergistically. These data and further in vitro studies involving artificial proteoglycans (KS/CS-albumin) and heat-denatured or reduced/alkylated proteoglycans suggested that all three components of the proteoglycan moiety, i.e., the core protein, CS chains, and KS chains, were required for the inhibitory activity of proteoglycans. We conclude that KS is essential for, and has an impact comparable to that of CS on, postinjury plasticity. Our study also established that KS and CS are independent requirements for the proteoglycan-mediated inhibition of axonal regeneration/sprouting. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Society for Neuroscience | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1523/JNEUROSCI.5120-10.2011 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0270-6474 | |||||
書誌情報 |
en : The Journal of Neuroscience 巻 31, 号 47, p. 17091-17102, 発行日 2011-11 |
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値 | publisher | |||||
URI | ||||||
識別子 | https://doi.org/10.1523/JNEUROSCI.5120-10.2011 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25434 | |||||
識別子タイプ | HDL |