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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

N-Acetylglucosamine 6-O-Sulfotransferase-1-Deficient Mice Show Better Functional Recovery after Spinal Cord Injury

http://hdl.handle.net/2237/25435
http://hdl.handle.net/2237/25435
c12243e9-70ea-4a2b-87d4-860edd3a00ab
名前 / ファイル ライセンス アクション
5937_full.pdf 5937_full.pdf (3.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-19
タイトル
タイトル N-Acetylglucosamine 6-O-Sulfotransferase-1-Deficient Mice Show Better Functional Recovery after Spinal Cord Injury
言語 en
著者 Ito, Zenya

× Ito, Zenya

WEKO 69010

en Ito, Zenya

Search repository
Sakamoto, Kazuma

× Sakamoto, Kazuma

WEKO 69011

en Sakamoto, Kazuma

Search repository
Imagama, Shiro

× Imagama, Shiro

WEKO 69012

en Imagama, Shiro

Search repository
Matsuyama, Yukihiro

× Matsuyama, Yukihiro

WEKO 69013

en Matsuyama, Yukihiro

Search repository
Zhang, Haoqian

× Zhang, Haoqian

WEKO 69014

en Zhang, Haoqian

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Hirano, Kenichi

× Hirano, Kenichi

WEKO 69015

en Hirano, Kenichi

Search repository
Ando, Kei

× Ando, Kei

WEKO 69016

en Ando, Kei

Search repository
Yamashita, Toshihide

× Yamashita, Toshihide

WEKO 69017

en Yamashita, Toshihide

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 69018

en Ishiguro, Naoki

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 69019

en Kadomatsu, Kenji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Copyright(c)2010 the authors
抄録
内容記述 Neurons in the adult CNS do not spontaneously regenerate after injuries. The glycosaminoglycan keratan sulfate is induced after spinal cord injury, but its biological significance is not well understood. Here we investigated the role of keratan sulfate in functional recovery after spinal cord injury, using mice deficient in N-acetylglucosamine 6-O-sulfotransferase-1 that lack 5D4-reactive keratan sulfate in the CNS. We made contusion injuries at the 10th thoracic level. Expressions of N-acetylglucosamine 6-O-sulfotransferase-1 and keratan sulfate were induced after injury in wild-type mice, but not in the deficient mice. The wild-type and deficient mice showed similar degrees of chondroitin sulfate induction and of CD11b-positive inflammatory cell recruitment. However, motor function recovery, as assessed by the footfall test, footprint test, and Basso mouse scale locomotor scoring, was significantly better in the deficient mice. Moreover, the deficient mice showed a restoration of neuromuscular system function below the lesion after electrical stimulation at the occipito-cervical area. In addition, axonal regrowth of both the corticospinal and raphespinal tracts was promoted in the deficient mice. In vitro assays using primary cerebellar granule neurons demonstrated that keratan sulfate proteoglycans were required for the proteoglycan-mediated inhibition of neurite outgrowth. These data collectively indicate that keratan sulfate expression is closely associated with functional disturbance after spinal cord injury. N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice are a good model to investigate the roles of keratan sulfate in the CNS.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Society for Neuroscience
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1523/JNEUROSCI.2570-09.2010
ISSN
収録物識別子タイプ PISSN
収録物識別子 0270-6474
書誌情報 en : Journal of Neuroscience

巻 30, 号 17, p. 5937-5947, 発行日 2010-04
著者版フラグ
値 publisher
URI
識別子 https://doi.org/10.1523/JNEUROSCI.2570-09.2010
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25435
識別子タイプ HDL
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