{"created":"2021-03-01T06:31:14.571223+00:00","id":23386,"links":{},"metadata":{"_buckets":{"deposit":"c354182b-af19-422a-be89-a2f1727305e7"},"_deposit":{"id":"23386","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23386"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00023386","sets":["499:500:501"]},"author_link":["69336","69337","69338","69339","69340","69341","69342"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"263","bibliographicPageStart":"256","bibliographicVolumeNumber":"164","bibliographic_titles":[{"bibliographic_title":"Journal of Photochemistry and Photobiology B: Biology","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Impairment of the activities of daily living (ADL) by osteoporosis is an important concern in developed countries with a super-aging population. Vitamin D, which is a crucial molecule in bone metabolism and mainly produced endogenously with ultraviolet (UV) light exposure, is known to be insufficient in the elderly population. We used an UV Light-Emitting Diode (UV-LED) instrument generating a narrow-range wavelength to analyze the efficacy of endogenous vitamin D production. The primary purpose of this study was to examine the effects of UV irradiation at various narrow-range wavelengths using UV-LED on vitamin D supplementation. The second one was to clarify the short-term effects of UV irradiation on bone morphology in mice. Vitamin D-starved C57BL/6 female mice (n = 7 per group) were UV-irradiated (268 nm, 282 nm, 290 nm, 305 nm, and 316 nm) with 1 kJ/m2 twice a week for 4 weeks. UV irradiation using UV-LED had significant effects on increasing serum 25(OH)D levels in all wavelength groups (P < 0.001, all groups) as compared to a control group. Among irradiated groups, wavelength of 316 nm had a less marked effect on 25(OH)D production compared with other wavelengths at 1 week of UV irradiation (P < 0.05). Levels of 1,25(OH)2D were significantly increased after 4 weeks irradiation with UV-B or UV-C irradiation (P < 0.05). mRNA levels of vitamin D 25-hydroxylase were increased with UV-B or UV-C irradiation (268 nm–305 nm), significantly. Micro-CT examination revealed that short-term (4 weeks) UV-irradiation did not induce morphological change of mice in any group. This study provides essential information that narrow-range UV irradiation with LED can increase the endogenous production of vitamin D, and mRNA levels of the responsible enzyme. Although bone morphology was not altered by short-term UV irradiation in this study, an increase of serum vitamin D might improve bone morphology with long-term irradiation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://dx.doi.org/10.1016/j.jphotobiol.2016.09.036"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/25587"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphotobiol.2016.09.036","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1011-1344","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Morita, Daigo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Yoshitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Taisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikuta, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asano, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiguro, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69342","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-01"}],"displaytype":"detail","filename":"manuscript_text_revision.pdf","filesize":[{"value":"594.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"manuscript_text_revision.pdf ファイル公開：2018/11/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/23386/files/manuscript_text_revision.pdf"},"version_id":"118c9e1b-9f1e-4483-a0b5-1e32dca29c40"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ultraviolet","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin D","subitem_subject_scheme":"Other"},{"subitem_subject":"Light emitting diode","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone morphology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Short-range ultraviolet irradiation with LED device effectively increases serum levels of 25(OH)D","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Short-range ultraviolet irradiation with LED device effectively increases serum levels of 25(OH)D","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-02-16"},"publish_date":"2017-02-16","publish_status":"0","recid":"23386","relation_version_is_last":true,"title":["Short-range ultraviolet irradiation with LED device effectively increases serum levels of 25(OH)D"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T05:05:23.447465+00:00"}