{"_buckets": {"deposit": "7a5f3467-e61c-4bf2-b229-7b85a4581daa"}, "_deposit": {"id": "23417", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23417"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00023417"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "1463", "bibliographicPageStart": "1456", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Surgery Today"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Purposes: The aim of this study was to investigate the effects of the preoperative administration of BV on the healing process of intestinal anastomosis in a rabbit model. Methods: Twenty male white rabbits were randomly divided into two groups. The control group received saline 1 week before surgery, and the BV group received intravenous BV 1 week before surgery. Each rabbit underwent an enteroenterostomy and a colocolostomy. On postoperative day 7, the bursting pressures of the anastomoses, CD31 and \u03b1-smooth muscle actin (\u03b1-SMA) staining by immunohistochemistry, the gene expression of \u03b1-SMA, and collagen deposition using Picrosirius Red at the site of anastomosis were evaluated. Results: The bursting pressure of small bowel anastomoses was significantly lower in the BV group than in the control group (control 184 \u00b1 10 mmHg vs. BV 140 \u00b1 9 mmHg; p = 0.004). The microvessel counts in the anastomotic tissue were significantly lower in the BV group than in the control group in both the small bowel (p = 0.023) and colon (p = 0.008). The expression of \u03b1-SMA, and the degree of collagen deposition decreased in the anastomotic tissue in the BV group compared with the control group. Conclusion: The preoperative use of BV may therefore negatively affect the rigidity of intestinal anastomosis.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1007/s00595-016-1342-4"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/25612"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at Springer via http://doi.org/10.1007/s00595-016-1342-4"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0941-1291", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Hayato"}], "nameIdentifiers": [{"nameIdentifier": "69437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Yukihiro"}], "nameIdentifiers": [{"nameIdentifier": "69438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uehara, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "69439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kokuryo, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "69440", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Junpei"}], "nameIdentifiers": [{"nameIdentifier": "69441", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuzuki, Toyonori"}], "nameIdentifiers": [{"nameIdentifier": "69442", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagino, Masato"}], "nameIdentifiers": [{"nameIdentifier": "69443", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "article.pdf", "filesize": [{"value": "880.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 880200.0, "url": {"label": "article.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2017/12/01", "url": "https://nagoya.repo.nii.ac.jp/record/23417/files/article.pdf"}, "version_id": "f212741c-0236-4c71-9b27-e5aaad69a067"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Bevacizumab", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intestinal anastomotic healing", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Anastomotic leakage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Angiogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b1-Smooth muscle actin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The effects of bevacizumab on intestinal anastomotic healing in rabbits", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The effects of bevacizumab on intestinal anastomotic healing in rabbits"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/25612", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-20"}, "publish_date": "2017-02-20", "publish_status": "0", "recid": "23417", "relation": {}, "relation_version_is_last": true, "title": ["The effects of bevacizumab on intestinal anastomotic healing in rabbits"], "weko_shared_id": null}