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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The effects of bevacizumab on intestinal anastomotic healing in rabbits

http://hdl.handle.net/2237/25612
http://hdl.handle.net/2237/25612
00b03921-9cf0-48a6-a409-a3887c57c545
名前 / ファイル ライセンス アクション
article.pdf article.pdf ファイル公開:2017/12/01 (880.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-20
タイトル
タイトル The effects of bevacizumab on intestinal anastomotic healing in rabbits
言語 en
著者 Nakamura, Hayato

× Nakamura, Hayato

WEKO 69437

en Nakamura, Hayato

Search repository
Yokoyama, Yukihiro

× Yokoyama, Yukihiro

WEKO 69438

en Yokoyama, Yukihiro

Search repository
Uehara, Keisuke

× Uehara, Keisuke

WEKO 69439

en Uehara, Keisuke

Search repository
Kokuryo, Toshio

× Kokuryo, Toshio

WEKO 69440

en Kokuryo, Toshio

Search repository
Yamaguchi, Junpei

× Yamaguchi, Junpei

WEKO 69441

en Yamaguchi, Junpei

Search repository
Tsuzuki, Toyonori

× Tsuzuki, Toyonori

WEKO 69442

en Tsuzuki, Toyonori

Search repository
Nagino, Masato

× Nagino, Masato

WEKO 69443

en Nagino, Masato

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s00595-016-1342-4
キーワード
主題Scheme Other
主題 Bevacizumab
キーワード
主題Scheme Other
主題 Intestinal anastomotic healing
キーワード
主題Scheme Other
主題 Anastomotic leakage
キーワード
主題Scheme Other
主題 Angiogenesis
キーワード
主題Scheme Other
主題 α-Smooth muscle actin
抄録
内容記述 Purposes: The aim of this study was to investigate the effects of the preoperative administration of BV on the healing process of intestinal anastomosis in a rabbit model. Methods: Twenty male white rabbits were randomly divided into two groups. The control group received saline 1 week before surgery, and the BV group received intravenous BV 1 week before surgery. Each rabbit underwent an enteroenterostomy and a colocolostomy. On postoperative day 7, the bursting pressures of the anastomoses, CD31 and α-smooth muscle actin (α-SMA) staining by immunohistochemistry, the gene expression of α-SMA, and collagen deposition using Picrosirius Red at the site of anastomosis were evaluated. Results: The bursting pressure of small bowel anastomoses was significantly lower in the BV group than in the control group (control 184 ± 10 mmHg vs. BV 140 ± 9 mmHg; p = 0.004). The microvessel counts in the anastomotic tissue were significantly lower in the BV group than in the control group in both the small bowel (p = 0.023) and colon (p = 0.008). The expression of α-SMA, and the degree of collagen deposition decreased in the anastomotic tissue in the BV group compared with the control group. Conclusion: The preoperative use of BV may therefore negatively affect the rigidity of intestinal anastomosis.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00595-016-1342-4
ISSN
収録物識別子タイプ PISSN
収録物識別子 0941-1291
書誌情報 en : Surgery Today

巻 46, 号 12, p. 1456-1463, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s00595-016-1342-4
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25612
識別子タイプ HDL
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