@article{oai:nagoya.repo.nii.ac.jp:00023417,
 author = {Nakamura, Hayato and Yokoyama, Yukihiro and Uehara, Keisuke and Kokuryo, Toshio and Yamaguchi, Junpei and Tsuzuki, Toyonori and Nagino, Masato},
 issue = {12},
 journal = {Surgery Today},
 month = {Dec},
 note = {Purposes: The aim of this study was to investigate the effects of the preoperative administration of BV on the healing process of intestinal anastomosis in a rabbit model. Methods: Twenty male white rabbits were randomly divided into two groups. The control group received saline 1 week before surgery, and the BV group received intravenous BV 1 week before surgery. Each rabbit underwent an enteroenterostomy and a colocolostomy. On postoperative day 7, the bursting pressures of the anastomoses, CD31 and α-smooth muscle actin (α-SMA) staining by immunohistochemistry, the gene expression of α-SMA, and collagen deposition using Picrosirius Red at the site of anastomosis were evaluated. Results: The bursting pressure of small bowel anastomoses was significantly lower in the BV group than in the control group (control 184 ± 10 mmHg vs. BV 140 ± 9 mmHg; p = 0.004). The microvessel counts in the anastomotic tissue were significantly lower in the BV group than in the control group in both the small bowel (p = 0.023) and colon (p = 0.008). The expression of α-SMA, and the degree of collagen deposition decreased in the anastomotic tissue in the BV group compared with the control group. Conclusion: The preoperative use of BV may therefore negatively affect the rigidity of intestinal anastomosis.},
 pages = {1456--1463},
 title = {The effects of bevacizumab on intestinal anastomotic healing in rabbits},
 volume = {46},
 year = {2016}
}