{"created":"2021-03-01T06:31:16.566930+00:00","id":23417,"links":{},"metadata":{"_buckets":{"deposit":"7a5f3467-e61c-4bf2-b229-7b85a4581daa"},"_deposit":{"id":"23417","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23417"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00023417","sets":["499:500:501"]},"author_link":["69437","69438","69439","69440","69441","69442","69443"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1463","bibliographicPageStart":"1456","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Surgery Today","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purposes: The aim of this study was to investigate the effects of the preoperative administration of BV on the healing process of intestinal anastomosis in a rabbit model. Methods: Twenty male white rabbits were randomly divided into two groups. The control group received saline 1 week before surgery, and the BV group received intravenous BV 1 week before surgery. Each rabbit underwent an enteroenterostomy and a colocolostomy. On postoperative day 7, the bursting pressures of the anastomoses, CD31 and α-smooth muscle actin (α-SMA) staining by immunohistochemistry, the gene expression of α-SMA, and collagen deposition using Picrosirius Red at the site of anastomosis were evaluated. Results: The bursting pressure of small bowel anastomoses was significantly lower in the BV group than in the control group (control 184 ± 10 mmHg vs. BV 140 ± 9 mmHg; p = 0.004). The microvessel counts in the anastomotic tissue were significantly lower in the BV group than in the control group in both the small bowel (p = 0.023) and colon (p = 0.008). The expression of α-SMA, and the degree of collagen deposition decreased in the anastomotic tissue in the BV group compared with the control group. Conclusion: The preoperative use of BV may therefore negatively affect the rigidity of intestinal anastomosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.1007/s00595-016-1342-4"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/25612"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00595-016-1342-4","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The final publication is available at Springer via http://doi.org/10.1007/s00595-016-1342-4","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0941-1291","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Hayato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoyama, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uehara, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokuryo, Toshio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Junpei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuzuki, Toyonori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagino, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"69443","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-01"}],"displaytype":"detail","filename":"article.pdf","filesize":[{"value":"880.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"article.pdf ファイル公開：2017/12/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/23417/files/article.pdf"},"version_id":"f212741c-0236-4c71-9b27-e5aaad69a067"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bevacizumab","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestinal anastomotic healing","subitem_subject_scheme":"Other"},{"subitem_subject":"Anastomotic leakage","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"α-Smooth muscle actin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effects of bevacizumab on intestinal anastomotic healing in rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effects of bevacizumab on intestinal anastomotic healing in rabbits","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-02-20"},"publish_date":"2017-02-20","publish_status":"0","recid":"23417","relation_version_is_last":true,"title":["The effects of bevacizumab on intestinal anastomotic healing in rabbits"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T05:05:24.650822+00:00"}