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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 79(1)

Polymorphisms of insulin receptor substrate 2 are putative biomarkers for pediatric medulloblastoma : considering the genetic susceptibility and pathological diagnoses

https://doi.org/10.18999/nagjms.79.1.47
https://doi.org/10.18999/nagjms.79.1.47
a1e3246a-bfed-4dee-bf5a-2140a2c8fa0f
名前 / ファイル ライセンス アクション
16_Wang.pdf 16_Wang.pdf (581.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-23
タイトル
タイトル Polymorphisms of insulin receptor substrate 2 are putative biomarkers for pediatric medulloblastoma : considering the genetic susceptibility and pathological diagnoses
著者 Wang, Baocheng

× Wang, Baocheng

WEKO 69489

Wang, Baocheng

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Zhao, Yang

× Zhao, Yang

WEKO 69490

Zhao, Yang

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Meng, Wei

× Meng, Wei

WEKO 69491

Meng, Wei

Search repository
Han, Yipeng

× Han, Yipeng

WEKO 69492

Han, Yipeng

Search repository
Wang, Jiajia

× Wang, Jiajia

WEKO 69493

Wang, Jiajia

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Liu, Feili

× Liu, Feili

WEKO 69494

Liu, Feili

Search repository
Qin, Shengying

× Qin, Shengying

WEKO 69495

Qin, Shengying

Search repository
Ma, Jie

× Ma, Jie

WEKO 69496

Ma, Jie

Search repository
キーワード
主題Scheme Other
主題 pediatric
キーワード
主題Scheme Other
主題 medulloblastoma
キーワード
主題Scheme Other
主題 pathology
キーワード
主題Scheme Other
主題 susceptibility
キーワード
主題Scheme Other
主題 prognosis
抄録
内容記述 Molecular profiling subgrouped medulloblastoma (MB) into four subtypes featured by distinct footprints. However, germline studies on genetic susceptibility in Chinese population have not been reported. To investigate the correlation of polymorphisms involved in the AKT signaling pathway with clinicopathological parameters in pediatric MB, and their contribution to the clinical outcome, we performed a case-controlled cohort consisting of 48 patients with pediatric MB and 190 healthy controls from Han population. Significant association in rs7987237 of insulin receptor substrate 2 (IRS2) was identified as risk allele/genotype between MB patients and control group (P<0.05). The allele “C” of rs7987237 in IRS2 gene was associated with an increased risk of MB (P=0.025; OR=2.95, 95%CI 1.43–6.11) after Bonferroni correction. Among 48 patients, various genotypes of rs7987237 show significant association with pathological diagnosis and metastases risk (P<0.05). Furthermore, the survival curve of patients with genotype “CC” of rs7987237 was confirmed with better outcome (P<0.001). Combined with previous results, our study suggests that polymorphisms of IRS2 putatively participated in the development of pediatric MB development. Therefore, it may benefit the early diagnosis and indicate the prognosis of patients with MB in Han population.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.79.1.47
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 79, 号 1, p. 47-54, 発行日 2017-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/791.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/25621
識別子タイプ HDL
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