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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age

http://hdl.handle.net/2237/25655
http://hdl.handle.net/2237/25655
60dc48b3-f9cd-41e3-af88-8d1edb1acc0e
名前 / ファイル ライセンス アクション
Yokoi_Y_Kondo_T_et_al_figure_Prev_Med_90_2016_201-206.pdf Yokoi_Y_Kondo_T_et_al_figure_Prev_Med_90_2016_201-206.pdf ファイル公開:2017/09/01 (260.6 kB)
Yokoi_Y_Kondo_T_et_al_article_Prev_Med_90_2016_201-206.pdf Yokoi_Y_Kondo_T_et_al_article_Prev_Med_90_2016_201-206.pdf ファイル公開:2017/09/01 (393.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-02
タイトル
タイトル Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age
言語 en
著者 Yokoi, Yuki

× Yokoi, Yuki

WEKO 69658

en Yokoi, Yuki

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Kondo, Takahisa

× Kondo, Takahisa

WEKO 69659

en Kondo, Takahisa

Search repository
Okumura, Naoki

× Okumura, Naoki

WEKO 69660

en Okumura, Naoki

Search repository
Shimokata, Keiko

× Shimokata, Keiko

WEKO 69661

en Shimokata, Keiko

Search repository
Osugi, Shigeki

× Osugi, Shigeki

WEKO 69662

en Osugi, Shigeki

Search repository
Maeda, Kengo

× Maeda, Kengo

WEKO 69663

en Maeda, Kengo

Search repository
Murohara, Toyoaki

× Murohara, Toyoaki

WEKO 69664

en Murohara, Toyoaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
抄録
内容記述 Background: Serum uric acid level is a predictor of future hypertension. However, its dependence on body mass index or age is unclear. Methods: We examined 26,442 Japanese males aged 18–60 years free from hypertension or diagnosed cardiovascular disease at baseline followed up between 2000 and 2010. Participants were categorized into three groups according to the tertile of serum uric acid levels [mg/dL; 1st (reference): 0.1–5.3; 2nd: 5.4–6.2; 3rd: 6.3–11.6]. Incident hypertension was defined as newly detected blood pressure ≥ 140/90 mm Hg and/or antihypertensive drugs initiation. Body mass index (< 25 kg/m2 vs. ≥ 25 kg/m2) and age (< 40 years vs. ≥ 40 years) were stratified into two groups. Results: During a mean follow-up of 7.2 years, there were 11,361 (43%) hypertension cases. Mean serum uric acid levels (mg/dL) at baseline in each group were 1st tertile, 4.6; 2nd tertile, 5.8; and 3rd tertile, 7.0. The cumulative incident hypertension rate was significantly higher in the 3rd tertile (50.8%) than in the 1st (37.4%). Multiple-adjusted hazard ratios (95% confidence interval) for incident hypertension compared with 1st tertile were 1.01 (0.96–1.05) and 1.15 (1.10–1.21) in the 2nd and 3rd tertile, respectively. There was a significant interaction between age and serum uric acid level (p for interaction = 0.035). In subjects aged ≥ 40 years, the 3rd serum uric acid group showed higher hazard ratios [1.48 (1.38–1.59)]. Conclusion: High serum uric acid level was associated with future hypertension in young and middle-aged Japanese males. This association was stronger among subjects ≥ 40 years old.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ypmed.2016.07.007
ISSN
収録物識別子タイプ PISSN
収録物識別子 0091-7435
書誌情報 en : Preventive Medicine

巻 90, p. 201-206, 発行日 2016-09
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1016/j.ypmed.2016.07.007
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25655
識別子タイプ HDL
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