ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "81f51c48-8ece-418c-9bb5-2e2d9b0e5786"}, "_deposit": {"id": "23502", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23502"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00023502", "sets": ["501"]}, "author_link": ["69723", "69724", "69725", "69726", "69727", "69728"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-10-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "E484", "bibliographicPageStart": "E477", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "Journal of Tissue Engineering and Regenerative Medicine", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Reinnervation of denervated muscle by motor neurons transplanted into the peripheral nerve may provide the potential to excite muscles artificially with functional electrical stimulation (FES). Here we investigated whether transplantation of embryonic motor neurons into peripheral nerve combined with FES restored functional muscle activity in adult Fischer 344 rats after transection of the sciatic nerve. One week after sciatic nerve transection, cell culture medium containing (cell transplantation group, n = 6) or lacking (surgical control group, n = 6) dissociated embryonic spinal neurons was injected into the distal stump of the tibial and peroneal nerves. Electrophysiological and tissue analyses were performed in the cell transplantation and surgical control groups 12 weeks after transplantation, as well as a in naïve control group (n = 6) that received no surgery. In the cell transplantation group, ankle angle was measured during gait, with and without FES of the peroneal nerve. Ankle angle at mid-swing was more flexed during gait with FES (26.6 ± 8.7°) than gait without FES (51.4 ± 12.8°, p = 0.011), indicating that transplantated motor neurons in conjunction with FES restored ankle flexion in gait, even though no neural connection between central nervous system and muscle was present. These results indicate that transplantation of embryonic motor neurons into peripheral nerve combined with FES can provide a novel treatment strategy for paralysed muscles.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1002/term.1844"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/25696"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/term.1844", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Kurimoto, S., Kato, S., Nakano, T., Yamamoto, M., Takanobu, N., and Hirata, H. (2016) Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model. J Tissue Eng Regen Med, 10: E477–E484. doi: 10.1002/term.1844.\u003cbr/\u003e], which has been published in final form at [http://doi.org/10.1002/term.1844]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6254", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kurimoto, Shigeru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69723", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Shuichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69724", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Tomonori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69725", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Michiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishizaka, Takanobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69728", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Transplantation_of_Embryonic_Motoneurons.pdf", "filesize": [{"value": "6.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 6300000.0, "url": {"label": "Transplantation_of_Embryonic_Motoneurons.pdf ファイル公開:2017/10/12", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/23502/files/Transplantation_of_Embryonic_Motoneurons.pdf"}, "version_id": "2e643837-ef0f-4980-bfe5-448724d2d820"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/25696", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-03-13"}, "publish_date": "2017-03-13", "publish_status": "0", "recid": "23502", "relation": {}, "relation_version_is_last": true, "title": ["Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model

http://hdl.handle.net/2237/25696
http://hdl.handle.net/2237/25696
c63d80ec-4db7-49da-b037-3f3aca105575
名前 / ファイル ライセンス アクション
Transplantation_of_Embryonic_Motoneurons.pdf Transplantation_of_Embryonic_Motoneurons.pdf ファイル公開:2017/10/12 (6.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-13
タイトル
タイトル Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model
言語 en
著者 Kurimoto, Shigeru

× Kurimoto, Shigeru

WEKO 69723

en Kurimoto, Shigeru

Search repository
Kato, Shuichi

× Kato, Shuichi

WEKO 69724

en Kato, Shuichi

Search repository
Nakano, Tomonori

× Nakano, Tomonori

WEKO 69725

en Nakano, Tomonori

Search repository
Yamamoto, Michiro

× Yamamoto, Michiro

WEKO 69726

en Yamamoto, Michiro

Search repository
Nishizaka, Takanobu

× Nishizaka, Takanobu

WEKO 69727

en Nishizaka, Takanobu

Search repository
Hirata, Hitoshi

× Hirata, Hitoshi

WEKO 69728

en Hirata, Hitoshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Kurimoto, S., Kato, S., Nakano, T., Yamamoto, M., Takanobu, N., and Hirata, H. (2016) Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model. J Tissue Eng Regen Med, 10: E477–E484. doi: 10.1002/term.1844.<br/>], which has been published in final form at [http://doi.org/10.1002/term.1844]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Reinnervation of denervated muscle by motor neurons transplanted into the peripheral nerve may provide the potential to excite muscles artificially with functional electrical stimulation (FES). Here we investigated whether transplantation of embryonic motor neurons into peripheral nerve combined with FES restored functional muscle activity in adult Fischer 344 rats after transection of the sciatic nerve. One week after sciatic nerve transection, cell culture medium containing (cell transplantation group, n = 6) or lacking (surgical control group, n = 6) dissociated embryonic spinal neurons was injected into the distal stump of the tibial and peroneal nerves. Electrophysiological and tissue analyses were performed in the cell transplantation and surgical control groups 12 weeks after transplantation, as well as a in naïve control group (n = 6) that received no surgery. In the cell transplantation group, ankle angle was measured during gait, with and without FES of the peroneal nerve. Ankle angle at mid-swing was more flexed during gait with FES (26.6 ± 8.7°) than gait without FES (51.4 ± 12.8°, p = 0.011), indicating that transplantated motor neurons in conjunction with FES restored ankle flexion in gait, even though no neural connection between central nervous system and muscle was present. These results indicate that transplantation of embryonic motor neurons into peripheral nerve combined with FES can provide a novel treatment strategy for paralysed muscles.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/term.1844
ISSN
収録物識別子タイプ PISSN
収録物識別子 1932-6254
書誌情報 en : Journal of Tissue Engineering and Regenerative Medicine

巻 10, 号 10, p. E477-E484, 発行日 2016-10-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/term.1844
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25696
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:32:47.468399
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3