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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery

http://hdl.handle.net/2237/25729
http://hdl.handle.net/2237/25729
39bb6b85-df17-4016-bf36-d10221486750
名前 / ファイル ライセンス アクション
manuscript.pdf manuscript.pdf ファイル公開:2017/12/01 (448.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-17
タイトル
タイトル Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery
言語 en
著者 Iida, Yuki

× Iida, Yuki

WEKO 69883

en Iida, Yuki

Search repository
Yamazaki, Takenori

× Yamazaki, Takenori

WEKO 69884

en Yamazaki, Takenori

Search repository
Arima, Hajime

× Arima, Hajime

WEKO 69885

en Arima, Hajime

Search repository
Kawabe, Tsutomu

× Kawabe, Tsutomu

WEKO 69886

en Kawabe, Tsutomu

Search repository
Yamada, Sumio

× Yamada, Sumio

WEKO 69887

en Yamada, Sumio

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
抄録
内容記述 Background: Muscle proteolysis due to post-operative hypercatabolism is responsible for the functional decline observed in patients undergoing cardiac surgery. The aim of this study was to explore the factors underlying increased muscle proteolysis by measuring the urinary 3-methylhistidine/creatinine ratio (3-MH/Cr) in patients who had recently undergone cardiac surgery. Methods and results: Sixty-nine patients undergoing elective cardiac surgery participated in this study. The 24-h urinary 3-MH/Cr was collected for 3 days after surgery. Serum levels of metabolic markers, amino acids, and skeletal muscle strength were measured before and after surgery. Cumulative 3-MH/Cr during 3 days after surgery (cum3-MH/Cr) was 676.7 ± 169.0 nmol/g Cr, and was positively associated with the decrease in muscle strength. In multivariate analysis, factors associated with an increased cum3-MH/Cr were preoperative grip strength (β = −0.309, p = 0.003), body mass index (β = −0.299, p = 0.001), hemoglobin (β = −0.243, p = 0.007), cardiopulmonary bypass time (β = 0.184, p = 0.049), and immediate post-operative interleukin-6 (β = 0.295, p = 0.002). Conclusions: Our findings suggest that post-operative muscle proteolysis is facilitated by preoperative catabolic accelerators in patients undergoing cardiac surgery. The factors of muscle proteolysis immediately after surgery may be a novel therapeutic target in rehabilitation intervention.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jjcc.2015.11.011
ISSN
収録物識別子タイプ PISSN
収録物識別子 0914-5087
書誌情報 en : Journal of Cardiology

巻 68, 号 6, p. 536-541, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1016/j.jjcc.2015.11.011
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25729
識別子タイプ HDL
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