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Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery
http://hdl.handle.net/2237/25729
http://hdl.handle.net/2237/2572939bb6b85-df17-4016-bf36-d10221486750
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-17 | |||||
タイトル | ||||||
タイトル | Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery | |||||
言語 | en | |||||
著者 |
Iida, Yuki
× Iida, Yuki× Yamazaki, Takenori× Arima, Hajime× Kawabe, Tsutomu× Yamada, Sumio |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
抄録 | ||||||
内容記述 | Background: Muscle proteolysis due to post-operative hypercatabolism is responsible for the functional decline observed in patients undergoing cardiac surgery. The aim of this study was to explore the factors underlying increased muscle proteolysis by measuring the urinary 3-methylhistidine/creatinine ratio (3-MH/Cr) in patients who had recently undergone cardiac surgery. Methods and results: Sixty-nine patients undergoing elective cardiac surgery participated in this study. The 24-h urinary 3-MH/Cr was collected for 3 days after surgery. Serum levels of metabolic markers, amino acids, and skeletal muscle strength were measured before and after surgery. Cumulative 3-MH/Cr during 3 days after surgery (cum3-MH/Cr) was 676.7 ± 169.0 nmol/g Cr, and was positively associated with the decrease in muscle strength. In multivariate analysis, factors associated with an increased cum3-MH/Cr were preoperative grip strength (β = −0.309, p = 0.003), body mass index (β = −0.299, p = 0.001), hemoglobin (β = −0.243, p = 0.007), cardiopulmonary bypass time (β = 0.184, p = 0.049), and immediate post-operative interleukin-6 (β = 0.295, p = 0.002). Conclusions: Our findings suggest that post-operative muscle proteolysis is facilitated by preoperative catabolic accelerators in patients undergoing cardiac surgery. The factors of muscle proteolysis immediately after surgery may be a novel therapeutic target in rehabilitation intervention. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.jjcc.2015.11.011 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0914-5087 | |||||
書誌情報 |
en : Journal of Cardiology 巻 68, 号 6, p. 536-541, 発行日 2016-12 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1016/j.jjcc.2015.11.011 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25729 | |||||
識別子タイプ | HDL |