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Prognostic relevance of SAMSN1 expression in gastric cancer
http://hdl.handle.net/2237/26031
http://hdl.handle.net/2237/260311f7841c6-f426-4507-b33c-9f860305a98b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ol_12_6_4708_PDF.pdf ファイル公開: 2017-06-01 (957.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-04-19 | |||||
| タイトル | ||||||
| タイトル | Prognostic relevance of SAMSN1 expression in gastric cancer | |||||
| 言語 | en | |||||
| 著者 |
Kanda, Mitsuro
× Kanda, Mitsuro× Shimizu, Dai× Sueoka, Satoshi× Nomoto, Shuji× Oya, Hisaharu× Takami, Hideki× Ezaka, Kazuhiro× Hashimoto, Ryoji× Tanaka, Yuri× Kobayashi, Daisuke× Tanaka, Chie× Yamada, Suguru× Fujii, Tsutomu× Nakayama, Goro× Sugimoto, Hiroyuki× Koike, Masahiko× Fujiwara, Michitaka× Kodera, Yasuhiro |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The prognosis for patients with advanced gastric cancer (GC) remains poor. The identification of biomarkers relevant to the recurrence and metastasis of GC is advantageous for stratifying patients and proposing novel molecular targets. In the present study the oncological roles of SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1), a mediator of B‑cell function, were elucidated in GC. The expression and methylation status of SAMSN1 were investigated in a panel of 11 GC cell lines. Immunohistochemical staining was performed to determine the pattern of SAMSN1 protein expression in gastric tissues. The prognostic impact of SAMSN1 expression was determined by analyzing 175 pairs of surgically resected gastric tissues. A marked decrease in the level of SAMSN1 mRNA was detected in 8/11 GC cell lines as compared with that in a non‑transformed intestinal epithelium cell line (FHs 74) without promoter methylation. The mean expression level of SAMSN1 mRNA was reduced in GC tissues compared with normal adjacent tissues, an observation that was independent of tumor differentiation. The pattern of SAMSN1 protein expression was significantly correlated with that of SAMSN1 mRNA. Low SAMSN1 mRNA expression was significantly associated with tumor size (>60 mm; P=0.026) and shorter overall survival times (P=0.004). Multivariate analysis identified low SAMSN1 mRNA expression as an independent prognostic factor for poor overall survival (hazard ratio, 1.80; 95% confidence interval, 1.07–3.05; P=0.025). The difference in survival between the low and high SAMSN1 expression groups was more marked in patients with stage II/III GC compared to those with stage IV GC. In patients with stage II/III GC who underwent curative surgery, low SAMSN1 expression was associated with reduced disease free survival times. The results of the present study indicate that downregulation of SAMSN1 transcription may affect the progression and recurrence of GC, and therefore may represent a novel biomarker of GC. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3892/ijmm.2012.1173 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1792-1074 | |||||
| 書誌情報 |
en : Oncology Letters 巻 12, 号 6, p. 4708-4716, 発行日 2016-12 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | https://doi.org/10.3892/ijmm.2012.1173 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26031 | |||||
| 識別子タイプ | HDL | |||||
