ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "cd401b80-b218-4190-8c79-361a6d30f10c"}, "_deposit": {"id": "23849", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23849"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00023849"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "4716", "bibliographicPageStart": "4708", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "Oncology Letters"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The prognosis for patients with advanced gastric cancer (GC) remains poor. The identification of biomarkers relevant to the recurrence and metastasis of GC is advantageous for stratifying patients and proposing novel molecular targets. In the present study the oncological roles of SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1), a mediator of B\u2011cell function, were elucidated in GC. The expression and methylation status of SAMSN1 were investigated in a panel of 11 GC cell lines. Immunohistochemical staining was performed to determine the pattern of SAMSN1 protein expression in gastric tissues. The prognostic impact of SAMSN1 expression was determined by analyzing 175 pairs of surgically resected gastric tissues. A marked decrease in the level of SAMSN1 mRNA was detected in 8/11 GC cell lines as compared with that in a non\u2011transformed intestinal epithelium cell line (FHs 74) without promoter methylation. The mean expression level of SAMSN1 mRNA was reduced in GC tissues compared with normal adjacent tissues, an observation that was independent of tumor differentiation. The pattern of SAMSN1 protein expression was significantly correlated with that of SAMSN1 mRNA. Low SAMSN1 mRNA expression was significantly associated with tumor size (\u003e60 mm; P=0.026) and shorter overall survival times (P=0.004). Multivariate analysis identified low SAMSN1 mRNA expression as an independent prognostic factor for poor overall survival (hazard ratio, 1.80; 95% confidence interval, 1.07\u20133.05; P=0.025). The difference in survival between the low and high SAMSN1 expression groups was more marked in patients with stage II/III GC compared to those with stage IV GC. In patients with stage II/III GC who underwent curative surgery, low SAMSN1 expression was associated with reduced disease free survival times. The results of the present study indicate that downregulation of SAMSN1 transcription may affect the progression and recurrence of GC, and therefore may represent a novel biomarker of GC.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "https://doi.org/10.3892/ijmm.2012.1173"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/26031"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Spandidos Publications"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1792-1074", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kanda, Mitsuro"}], "nameIdentifiers": [{"nameIdentifier": "70792", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Dai"}], "nameIdentifiers": [{"nameIdentifier": "70793", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sueoka, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "70794", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nomoto, Shuji"}], "nameIdentifiers": [{"nameIdentifier": "70795", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oya, Hisaharu"}], "nameIdentifiers": [{"nameIdentifier": "70796", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takami, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "70797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ezaka, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "70798", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Ryoji"}], "nameIdentifiers": [{"nameIdentifier": "70799", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yuri"}], "nameIdentifiers": [{"nameIdentifier": "70800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "70801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Chie"}], "nameIdentifiers": [{"nameIdentifier": "70802", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Suguru"}], "nameIdentifiers": [{"nameIdentifier": "70803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujii, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "70804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Goro"}], "nameIdentifiers": [{"nameIdentifier": "70805", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugimoto, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "70806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koike, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "70807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujiwara, Michitaka"}], "nameIdentifiers": [{"nameIdentifier": "70808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodera, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "70809", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ol_12_6_4708_PDF.pdf", "filesize": [{"value": "957.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 957500.0, "url": {"label": "ol_12_6_4708_PDF.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b: 2017-06-01", "url": "https://nagoya.repo.nii.ac.jp/record/23849/files/ol_12_6_4708_PDF.pdf"}, "version_id": "9b7a3e7b-0273-40cf-89dd-ae803b6932cb"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Prognostic relevance of SAMSN1 expression in gastric cancer", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Prognostic relevance of SAMSN1 expression in gastric cancer"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/26031", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-04-19"}, "publish_date": "2017-04-19", "publish_status": "0", "recid": "23849", "relation": {}, "relation_version_is_last": true, "title": ["Prognostic relevance of SAMSN1 expression in gastric cancer"], "weko_shared_id": null}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Prognostic relevance of SAMSN1 expression in gastric cancer

http://hdl.handle.net/2237/26031
1f7841c6-f426-4507-b33c-9f860305a98b
名前 / ファイル ライセンス アクション
ol_12_6_4708_PDF.pdf ol_12_6_4708_PDF.pdf ファイル公開: 2017-06-01 (957.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-19
タイトル
タイトル Prognostic relevance of SAMSN1 expression in gastric cancer
著者 Kanda, Mitsuro

× Kanda, Mitsuro

WEKO 70792

Kanda, Mitsuro

Search repository
Shimizu, Dai

× Shimizu, Dai

WEKO 70793

Shimizu, Dai

Search repository
Sueoka, Satoshi

× Sueoka, Satoshi

WEKO 70794

Sueoka, Satoshi

Search repository
Nomoto, Shuji

× Nomoto, Shuji

WEKO 70795

Nomoto, Shuji

Search repository
Oya, Hisaharu

× Oya, Hisaharu

WEKO 70796

Oya, Hisaharu

Search repository
Takami, Hideki

× Takami, Hideki

WEKO 70797

Takami, Hideki

Search repository
Ezaka, Kazuhiro

× Ezaka, Kazuhiro

WEKO 70798

Ezaka, Kazuhiro

Search repository
Hashimoto, Ryoji

× Hashimoto, Ryoji

WEKO 70799

Hashimoto, Ryoji

Search repository
Tanaka, Yuri

× Tanaka, Yuri

WEKO 70800

Tanaka, Yuri

Search repository
Kobayashi, Daisuke

× Kobayashi, Daisuke

WEKO 70801

Kobayashi, Daisuke

Search repository
Tanaka, Chie

× Tanaka, Chie

WEKO 70802

Tanaka, Chie

Search repository
Yamada, Suguru

× Yamada, Suguru

WEKO 70803

Yamada, Suguru

Search repository
Fujii, Tsutomu

× Fujii, Tsutomu

WEKO 70804

Fujii, Tsutomu

Search repository
Nakayama, Goro

× Nakayama, Goro

WEKO 70805

Nakayama, Goro

Search repository
Sugimoto, Hiroyuki

× Sugimoto, Hiroyuki

WEKO 70806

Sugimoto, Hiroyuki

Search repository
Koike, Masahiko

× Koike, Masahiko

WEKO 70807

Koike, Masahiko

Search repository
Fujiwara, Michitaka

× Fujiwara, Michitaka

WEKO 70808

Fujiwara, Michitaka

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 70809

Kodera, Yasuhiro

Search repository
抄録
内容記述 The prognosis for patients with advanced gastric cancer (GC) remains poor. The identification of biomarkers relevant to the recurrence and metastasis of GC is advantageous for stratifying patients and proposing novel molecular targets. In the present study the oncological roles of SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1), a mediator of B‑cell function, were elucidated in GC. The expression and methylation status of SAMSN1 were investigated in a panel of 11 GC cell lines. Immunohistochemical staining was performed to determine the pattern of SAMSN1 protein expression in gastric tissues. The prognostic impact of SAMSN1 expression was determined by analyzing 175 pairs of surgically resected gastric tissues. A marked decrease in the level of SAMSN1 mRNA was detected in 8/11 GC cell lines as compared with that in a non‑transformed intestinal epithelium cell line (FHs 74) without promoter methylation. The mean expression level of SAMSN1 mRNA was reduced in GC tissues compared with normal adjacent tissues, an observation that was independent of tumor differentiation. The pattern of SAMSN1 protein expression was significantly correlated with that of SAMSN1 mRNA. Low SAMSN1 mRNA expression was significantly associated with tumor size (>60 mm; P=0.026) and shorter overall survival times (P=0.004). Multivariate analysis identified low SAMSN1 mRNA expression as an independent prognostic factor for poor overall survival (hazard ratio, 1.80; 95% confidence interval, 1.07–3.05; P=0.025). The difference in survival between the low and high SAMSN1 expression groups was more marked in patients with stage II/III GC compared to those with stage IV GC. In patients with stage II/III GC who underwent curative surgery, low SAMSN1 expression was associated with reduced disease free survival times. The results of the present study indicate that downregulation of SAMSN1 transcription may affect the progression and recurrence of GC, and therefore may represent a novel biomarker of GC.
内容記述タイプ Abstract
出版者
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1792-1074
書誌情報 Oncology Letters

巻 12, 号 6, p. 4708-4716, 発行日 2016-12
著者版フラグ
値 publisher
URI
識別子 https://doi.org/10.3892/ijmm.2012.1173
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26031
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:22:51.027956
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio