{"created":"2021-03-01T06:31:48.419962+00:00","id":23914,"links":{},"metadata":{"_buckets":{"deposit":"a8a5c70f-90f1-404f-b1a9-98fa220fc100"},"_deposit":{"id":"23914","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23914"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00023914","sets":["499:500:501"]},"author_link":["70998","70999","71000","71001","71002","71003"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1404","bibliographicPageStart":"1393","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Immunotherapy","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Patients with glioblastoma have a very poor prognosis. Adoptive cellular therapy (ACT) is defined as the collection of circulating or tumor-infiltrating lymphocytes, their selection, modification, expansion and activation, and their re-administration to patients in order to induce antitumor activity. Although various ACTs have been attempted, most failed to improve the outcome. Immune checkpoint blockade antibodies and T cell engineering with tumor-specific chimeric antigen receptors suggest the emergence of a new era of immunotherapy. Here, we summarize approaches with ACTs using genetically modified T cells, which have been improved by enhancing their antitumor activity, and discuss strategies to develop these therapies. The mechanisms by which gliomas modulate and evade the immune system are also discussed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"http://doi.org/10.2217/imt-2016-0076"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/26117"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Future Medicine","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2217/imt-2016-0076","subitem_relation_type_select":"DOI"}}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1750-743X","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuramitsu, Shunichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamichi, Akane","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"70999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohka, Fumiharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"71000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motomura, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"71001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Masahito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"71002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Natsume, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"71003","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-01"}],"displaytype":"detail","filename":"0815Review_Figures.pdf","filesize":[{"value":"334.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0815Review_Figures.pdf ファイル公開：2017/12/01","objectType":"dataset","url":"https://nagoya.repo.nii.ac.jp/record/23914/files/0815Review_Figures.pdf"},"version_id":"22838a25-7eec-4984-8ae0-2dbc6488fcdb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-01"}],"displaytype":"detail","filename":"20160815revision_kuramitsu_ACT_review_v11.pdf","filesize":[{"value":"249.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20160815revision_kuramitsu_ACT_review_v11.pdf ファイル公開：2017/12/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/23914/files/20160815revision_kuramitsu_ACT_review_v11.pdf"},"version_id":"c419b299-6256-494e-bfa9-070a7fa7583c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-04-21"},"publish_date":"2017-04-21","publish_status":"0","recid":"23914","relation_version_is_last":true,"title":["Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:45:19.124641+00:00"}