@article{oai:nagoya.repo.nii.ac.jp:00024166, author = {近藤, 志保 and 藤木, 理代 and 山本, 明子 and 石黒, 洋 and KONDO, Shiho and FUJIKI, Kotoyo and YAMAMOTO, Akiko and ISHIGURO, Hiroshi}, issue = {1}, journal = {総合保健体育科学}, month = {Dec}, note = {[Aim] The purpose of this study is to investigate whether the Trp64Arg polymorphism in β3-Adrenergic receptor (β3AR) gene and the Arg16Gly in β2AR were associated with glucose metabolism in aerobic and resistance exercise. [Methods] Thirteen healthy Japanese women (21~22 years old, BMI: 20.2±1.6) were recruited. The subjects performed 4-week aerobic exercise program (rhythmic dance) at 60% of their maximal heart rate for 20 min/day. After 4-weeks interval they performed 4-week resistance exercise program (sit up, back extension, overhead press, squat, twist) for 10 min/day. Before and after intervention 75-g oral glucose tolerance test were performed. [Results] Eight subjects have wild type (Trp64) of β3AR which is the genotype with high lipolysis activity. Other five subjects have Trp64Arg in β3AR or homozygote of Arg16Gly in β2AR they are the genotypes with high glucose metabolism. In the subjects with high lipolysis type the level of Δ30-50 min glucose was significantly higher during the aerobic exercise compare to that in resting (43.4±17.5 vs. -0.5±20.3 mg/dl, p<0.05). After the intervention the level was reduced to 23.3±26.5 mg/dl. The level of Δ30-45 min glucose during the resistance exercise was 23.0±30.9 mg/dl. After the intervention that was kept at significantly higher level compare to that in resting (25.3±24.6 vs. -0.5±17.1 mg/dl, p<0.05). In the subjects with high glucose metabolism the level during the aerobic exercise was significantly higher compare to that in resting (40.0±9.2 vs. 12.0±11.1 mg/dl, p<0.05). After the intervention the level was kept at 45.0±32.4 mg/dl. The level of Δ30-45 min glucose was significantly higher during the resistance exercise compare to that in resting (46.8±22.8 vs. -1.4±14.8 mg/dl, p<0.05). After the intervention the level was reduced to 11.6±26.0 mg/dl. [Conclusion] Trp64Arg in β3AR and the Arg16Gly in β2AR were associated with glucose metabolism in acute and chronic aerobic and resistance exercise.}, pages = {11--16}, title = {β3アドレナリン受容体およびβ2アドレナリン受容体遺伝子多型の運動時糖質代謝への寄与}, volume = {39}, year = {2016} }