@article{oai:nagoya.repo.nii.ac.jp:00024383,
 author = {Nakamura, Yoshiko and Yanagawa, Yuchio and Morrison, Shaun F. and Nakamura, Kazuhiro},
 issue = {2},
 journal = {Cell Metabolism},
 month = {Feb},
 note = {Hypothalamic neuropeptide Y (NPY) elicits hunger responses to increase the chances of surviving starvation: an inhibition of metabolism and an increase in feeding. Here we elucidate a key central circuit mechanism through which hypothalamic NPY signals drive these hunger responses. GABAergic neurons in the intermediate and parvicellular reticular nuclei (IRt/PCRt) of the medulla oblongata, which are activated by NPY-triggered neural signaling from the hypothalamus, potentially through the nucleus tractus solitarius, mediate the NPY-induced inhibition of metabolic thermogenesis in brown adipose tissue (BAT) via their innervation of BAT sympathetic premotor neurons. Intriguingly, the GABAergic IRt/PCRt neurons innervating the BAT sympathetic premotor region also innervate the masticatory motor region, and stimulation of the IRt/PCRt elicits mastication and increases feeding as well as inhibits BAT thermogenesis. These results indicate that GABAergic IRt/PCRt neurons mediate hypothalamus-derived hunger signaling by coordinating both autonomic and feeding motor systems to reduce energy expenditure and to promote feeding.},
 pages = {322--334},
 title = {Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication},
 volume = {25},
 year = {2017}
}