{"created":"2021-03-01T06:32:19.553496+00:00","id":24383,"links":{},"metadata":{"_buckets":{"deposit":"e830a931-1a38-4720-b26e-f4570322591f"},"_deposit":{"id":"24383","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24383"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00024383","sets":["499:500:501"]},"author_link":["72225","72226","72227","72228"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"334","bibliographicPageStart":"322","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Cell Metabolism","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypothalamic neuropeptide Y (NPY) elicits hunger responses to increase the chances of surviving starvation: an inhibition of metabolism and an increase in feeding. Here we elucidate a key central circuit mechanism through which hypothalamic NPY signals drive these hunger responses. GABAergic neurons in the intermediate and parvicellular reticular nuclei (IRt/PCRt) of the medulla oblongata, which are activated by NPY-triggered neural signaling from the hypothalamus, potentially through the nucleus tractus solitarius, mediate the NPY-induced inhibition of metabolic thermogenesis in brown adipose tissue (BAT) via their innervation of BAT sympathetic premotor neurons. Intriguingly, the GABAergic IRt/PCRt neurons innervating the BAT sympathetic premotor region also innervate the masticatory motor region, and stimulation of the IRt/PCRt elicits mastication and increases feeding as well as inhibits BAT thermogenesis. These results indicate that GABAergic IRt/PCRt neurons mediate hypothalamus-derived hunger signaling by coordinating both autonomic and feeding motor systems to reduce energy expenditure and to promote feeding.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"DOI","subitem_identifier_uri":"https://doi.org/10.1016/j.cmet.2016.12.002"},{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/26594"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.cmet.2016.12.002","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1550-4131","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Yoshiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"72225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagawa, Yuchio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"72226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morrison, Shaun F.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"72227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"72228","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-01"}],"displaytype":"detail","filename":"Final_manuscript.pdf","filesize":[{"value":"9.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Final_manuscript.pdf ファイル公開：2018/02/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/24383/files/Final_manuscript.pdf"},"version_id":"89e93058-bdda-4fea-93a4-5b12fcf8a374"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-06-07"},"publish_date":"2017-06-07","publish_status":"0","recid":"24383","relation_version_is_last":true,"title":["Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:45:30.066182+00:00"}