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Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease
http://hdl.handle.net/2237/26634
http://hdl.handle.net/2237/26634a489110a-261d-4c88-9c1d-f44c4e877ac2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
suzuki-main13.pdf ファイル公開：2018/02/01 (732.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-06-09 | |||||
| タイトル | ||||||
| タイトル | Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease | |||||
| 言語 | en | |||||
| 著者 |
Suzuki, Masashi
× Suzuki, Masashi× Nakamura, Tomohiko× Hirayama, Masaaki× Ueda, Miki× Katsuno, Masahisa× Sobue, Gen |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | The final publication is available at Springer via http://doi.org/10.1007/s00415-016-8348-0 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Parkinson’s disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardiac parasympathetic dysfunction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardiac 123I-metaiodobenzylguanidine scintigraphy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Autonomic dysfunction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Autonomic nervous system | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cardiac parasympathetic function is strongly affected by aging. Although sympathetic dysfunction has been well documented in Parkinson’s disease (PD), cardiac parasympathetic dysfunction has not been well studied. The objective of this study was to clarify the development of cardiac parasympathetic dysfunction in the early phase of PD and to explore the age-corrected correlation between cardiac parasympathetic dysfunction and cardiac sympathetic dysfunction. We reviewed 25 healthy controls and 56 patients with idiopathic PD of Hoehn and Yahr stages I–III. We evaluated cardiac parasympathetic function using the Valsalva ratio, the baroreflex sensitivity (BRS) and the coefficient of variation of RR intervals in the resting state (resting-CVRR) and during deep breathing (DB-CVRR). In addition, we measured cardiac 123I-metaiodobenzylguanidine (MIBG) uptake to investigate the relationship between cardiac sympathetic and parasympathetic dysfunction in PD. Compared with healthy controls, patients with PD showed significantly decreased cardiac parasympathetic parameters (resting-CVRR 2.8 ± 1.3 vs. 1.7 ± 0.6%, p < 0.001; DB-CVRR 5.8 ± 2.3 vs. 3.8 ± 1.7%, p < 0.001; Valsalva ratio 1.52 ± 0.26 vs. 1.34 ± 0.17, p < 0.01; BRS 10.6 ± 9.5 vs. 5.0 ± 5.4 ms/mmHg, p < 0.01). In particular, resting-CVRR and DB-CVRR were significantly decreased in the early phase of PD. In age-corrected analyses, none of the parasympathetic indices correlated with the delayed cardiac 123I-MIBG uptake. These observations indicate that cardiac parasympathetic dysfunction occurs in the early phase of PD, but not necessarily in parallel with cardiac sympathetic dysfunction. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s00415-016-8348-0 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0340-5354 | |||||
| 書誌情報 |
en : Journal of Neurology 巻 264, 号 2, p. 333-340, 発行日 2017-02 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1007/s00415-016-8348-0 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26634 | |||||
| 識別子タイプ | HDL | |||||
