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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease

http://hdl.handle.net/2237/26634
a489110a-261d-4c88-9c1d-f44c4e877ac2
名前 / ファイル ライセンス アクション
suzuki-main13.pdf suzuki-main13.pdf ファイル公開:2018/02/01 (732.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-06-09
タイトル
タイトル Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease
著者 Suzuki, Masashi

× Suzuki, Masashi

WEKO 72365

Suzuki, Masashi

Search repository
Nakamura, Tomohiko

× Nakamura, Tomohiko

WEKO 72366

Nakamura, Tomohiko

Search repository
Hirayama, Masaaki

× Hirayama, Masaaki

WEKO 72367

Hirayama, Masaaki

Search repository
Ueda, Miki

× Ueda, Miki

WEKO 72368

Ueda, Miki

Search repository
Katsuno, Masahisa

× Katsuno, Masahisa

WEKO 72369

Katsuno, Masahisa

Search repository
Sobue, Gen

× Sobue, Gen

WEKO 72370

Sobue, Gen

Search repository
権利
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s00415-016-8348-0
キーワード
主題Scheme Other
主題 Parkinson’s disease
キーワード
主題Scheme Other
主題 Cardiac parasympathetic dysfunction
キーワード
主題Scheme Other
主題 Cardiac 123I-metaiodobenzylguanidine scintigraphy
キーワード
主題Scheme Other
主題 Autonomic dysfunction
キーワード
主題Scheme Other
主題 Autonomic nervous system
抄録
内容記述 Cardiac parasympathetic function is strongly affected by aging. Although sympathetic dysfunction has been well documented in Parkinson’s disease (PD), cardiac parasympathetic dysfunction has not been well studied. The objective of this study was to clarify the development of cardiac parasympathetic dysfunction in the early phase of PD and to explore the age-corrected correlation between cardiac parasympathetic dysfunction and cardiac sympathetic dysfunction. We reviewed 25 healthy controls and 56 patients with idiopathic PD of Hoehn and Yahr stages I–III. We evaluated cardiac parasympathetic function using the Valsalva ratio, the baroreflex sensitivity (BRS) and the coefficient of variation of RR intervals in the resting state (resting-CVRR) and during deep breathing (DB-CVRR). In addition, we measured cardiac 123I-metaiodobenzylguanidine (MIBG) uptake to investigate the relationship between cardiac sympathetic and parasympathetic dysfunction in PD. Compared with healthy controls, patients with PD showed significantly decreased cardiac parasympathetic parameters (resting-CVRR 2.8 ± 1.3 vs. 1.7 ± 0.6%, p < 0.001; DB-CVRR 5.8 ± 2.3 vs. 3.8 ± 1.7%, p < 0.001; Valsalva ratio 1.52 ± 0.26 vs. 1.34 ± 0.17, p < 0.01; BRS 10.6 ± 9.5 vs. 5.0 ± 5.4 ms/mmHg, p < 0.01). In particular, resting-CVRR and DB-CVRR were significantly decreased in the early phase of PD. In age-corrected analyses, none of the parasympathetic indices correlated with the delayed cardiac 123I-MIBG uptake. These observations indicate that cardiac parasympathetic dysfunction occurs in the early phase of PD, but not necessarily in parallel with cardiac sympathetic dysfunction.
内容記述タイプ Abstract
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0340-5354
書誌情報 Journal of Neurology

巻 264, 号 2, p. 333-340, 発行日 2017-02
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s00415-016-8348-0
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26634
識別子タイプ HDL
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