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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Phospholipid localization implies microglial morphology and function via Cdc42 in vitro

http://hdl.handle.net/2237/26657
4ed83b89-5f34-4d75-9de7-e72ed98d53b3
名前 / ファイル ライセンス アクション
Glia.pdf Glia.pdf ファイル公開:2018/05/01 (6.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-06-13
タイトル
タイトル Phospholipid localization implies microglial morphology and function via Cdc42 in vitro
著者 Tokizane, Kyohei

× Tokizane, Kyohei

WEKO 72463

Tokizane, Kyohei

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Konishi, Hiroyuki

× Konishi, Hiroyuki

WEKO 72464

Konishi, Hiroyuki

Search repository
Makide, Kumiko

× Makide, Kumiko

WEKO 72465

Makide, Kumiko

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Kawana, Hiroki

× Kawana, Hiroki

WEKO 72466

Kawana, Hiroki

Search repository
Nakamuta, Shinichi

× Nakamuta, Shinichi

WEKO 72467

Nakamuta, Shinichi

Search repository
Kaibuchi, Kozo

× Kaibuchi, Kozo

WEKO 72468

Kaibuchi, Kozo

Search repository
Ohwada, Tomohiko

× Ohwada, Tomohiko

WEKO 72469

Ohwada, Tomohiko

Search repository
Aoki, Junken

× Aoki, Junken

WEKO 72470

Aoki, Junken

Search repository
Kiyama, Hiroshi

× Kiyama, Hiroshi

WEKO 72471

Kiyama, Hiroshi

Search repository
権利
権利情報 "This is the peer reviewed version of the following article: [Tokizane K, Konishi H, Makide K, et al. Phospholipid localization implies microglial morphology and function via Cdc42 in vitro. Glia. 2017;65:740–755. https://doi.org/10.1002/glia.23123], which has been published in final form at [http://doi.org/10.1002/glia.23123]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
抄録
内容記述 Under a quiescent state, microglia exhibit a ramified shape, rather than the amoeboid-like morphology following injury or inflammation. The manipulation of microglial morphology in vitro has not been very successful, which has impeded the progress of microglial studies. We demonstrate that lysophosphatidylserine (LysoPS), a kind of lysophospholipids, rapidly and substantially alters the morphology of primary cultured microglia to an in vivo-like ramified shape in a receptor independent manner. This mechanism is mediated by Cdc42 activity. LysoPS is incorporated into the plasma membrane and converted to phosphatidylserine (PS) via the Lands' cycle. The accumulated PS on the membrane recruits Cdc42. Both Cdc42 and PS colocalize predominantly in primary and secondary processes, but not in peripheral branches or tips of microglia. Along with the morphological changes LysoPS suppresses inflammatory cytokine production and NF-kB activity. The present study provides a tool to manipulate a microglial phenotype from an amoeboid to a fully ramified in vitro, which certainly contributes to studies exploring microglial physiology and pathology.
内容記述タイプ Abstract
出版者
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0894-1491
書誌情報 GLIA

巻 65, 号 5, p. 740-755, 発行日 2017-05
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/glia.23123
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26657
識別子タイプ HDL
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