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Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases
http://hdl.handle.net/2237/26785
http://hdl.handle.net/2237/2678531df3baa-969f-488e-a8ae-e116e3588337
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
RMED-D-17-00015_R2.pdf ファイル公開：2018/04/01 (342.8 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-07-11 | |||||
| タイトル | ||||||
| タイトル | Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases | |||||
| 言語 | en | |||||
| 著者 |
Taoka, Toshiaki
× Taoka, Toshiaki× Masutani, Yoshitaka× Kawai, Hisashi× Nakane, Toshiki× Matsuoka, Kiwamu× Yasuno, Fumihiko× Kishimoto, Toshifumi× Naganawa, Shinji |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at Springer via http://doi.org/10.1007/s11604-017-0617-z | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glymphatic system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Alzheimer’s disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MRI | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Diffusion tensor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Perivascular space | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The activity of the glymphatic system is impaired in animal models of Alzheimer’s disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS). Materials and methods: Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score. Results: We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity. Conclusion: Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s11604-017-0617-z | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1867-1071 | |||||
| 書誌情報 |
en : Japanese Journal of Radiology 巻 35, 号 4, p. 172-178, 発行日 2017-04 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1007/s11604-017-0617-z | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26785 | |||||
| 識別子タイプ | HDL | |||||
