{"created":"2021-03-01T06:32:36.939140+00:00","id":24649,"links":{},"metadata":{"_buckets":{"deposit":"555690c0-ba9f-4581-a497-2a9ff2316b6f"},"_deposit":{"id":"24649","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24649"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00024649","sets":["499:500:501"]},"author_link":["73012","73013","73014","73015","73016","73017","73018","73019","73020","73021","73022","73023"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1896","bibliographicPageStart":"1892","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters","bibliographic_titleLang":"en"}]}]},"item_10_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"O^6-Benzylguanine (O^6-BG) is a substrate of O^6-methylguanine-DNA methyltransferase (MGMT), which is involved in drug resistance of chemotherapy in the majority of glioblastoma multiform. For clinical diagnosis, it is hoped that the MGMT expression level could be determined by a noninvasive method to understand the detailed biological properties of MGMT-specific tumors. We synthesized 11C-labeled O^6-[(3-methyl)benzyl]guanine ([11C]mMeBG) as a positron emission tomography probe. Thus, a mixed amine-protected stannyl precursor, N9-(tert-butoxycarbonyl)-O^6-[3-(tributylstannyl)benzyl]-N2-(trifluoroacetyl)guanine, was subjected to rapid C-[11C]methylation under [11C]CH3I/[Pd2(dba)3]/P(o-CH3C6H4)3/CuCl/K2CO3 in NMP, followed by quick deprotection with LiOH/H2O, giving [11C]mMeBG with total radioactivity of 1.34 GBq and ≥99% radiochemical and chemical purities.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/26868"}]},"item_10_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmcl.2017.03.045","subitem_relation_type_select":"DOI"}}]},"item_10_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_10_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"PISSN"}]},"item_1615787544753":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koyama, Hiroko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikenuma, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toda, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Goro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Junichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakabayashi, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Kengo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Natsume, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"73023","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-01"}],"displaytype":"detail","filename":"170228_manuscript_MGMT_for_BMCL-D-16-02164_revised.pdf","filesize":[{"value":"796.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"170228_manuscript_MGMT_for_BMCL-D-16-02164_revised.pdf ファイル公開：2019/05/01","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/24649/files/170228_manuscript_MGMT_for_BMCL-D-16-02164_revised.pdf"},"version_id":"167d6d8d-83db-44a8-87e1-67bf18d2d38f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of PET probe O^6-[(3-[11C]methyl)benzyl]guanine by Pd^0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O^6-methylguanine-DNA methyltransferase in glioblastoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of PET probe O^6-[(3-[11C]methyl)benzyl]guanine by Pd^0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O^6-methylguanine-DNA methyltransferase in glioblastoma","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-08-02"},"publish_date":"2017-08-02","publish_status":"0","recid":"24649","relation_version_is_last":true,"title":["Synthesis of PET probe O^6-[(3-[11C]methyl)benzyl]guanine by Pd^0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O^6-methylguanine-DNA methyltransferase in glioblastoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T04:20:58.987238+00:00"}