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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Effects of cyclic compression on the mechanical properties and calcification process of immature chick bone tissue in culture

http://hdl.handle.net/2237/26877
http://hdl.handle.net/2237/26877
e6dc5117-e319-487e-ba92-213287584517
名前 / ファイル ライセンス アクション
1-s2_0-S2352187217300141-main.pdf 1-s2_0-S2352187217300141-main.pdf (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-03
タイトル
タイトル Effects of cyclic compression on the mechanical properties and calcification process of immature chick bone tissue in culture
言語 en
著者 Maeda, Eijiro

× Maeda, Eijiro

WEKO 73068

en Maeda, Eijiro

Search repository
Nakagaki, Masashi

× Nakagaki, Masashi

WEKO 73069

en Nakagaki, Masashi

Search repository
Ichikawa, Katsuhisa

× Ichikawa, Katsuhisa

WEKO 73070

en Ichikawa, Katsuhisa

Search repository
Nagayama, Kazuaki

× Nagayama, Kazuaki

WEKO 73071

en Nagayama, Kazuaki

Search repository
Matsumoto, Takeo

× Matsumoto, Takeo

WEKO 73072

en Matsumoto, Takeo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 ©2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
キーワード
主題Scheme Other
主題 Cyclic compression
キーワード
主題Scheme Other
主題 Mechanical loading
キーワード
主題Scheme Other
主題 Elastic modulus
キーワード
主題Scheme Other
主題 Calcification
キーワード
主題Scheme Other
主題 Ex vivo culture
抄録
内容記述 Contribution of mechanical loading to tissue growth during both the development and post-natal maturation is of a particular interest, as its understanding would be important to strategies in bone tissue engineering and regenerative medicine. The present study has been performed to investigate how immature bone responds to mechanical loading using an ex vivo culture system. A slice of the tibia, with the thickness of 3 mm, was obtained from 0-day-old chick. For the ex vivo culture experiment in conjunction with cyclic compressive loading, we developed a custom-made, bioreactor system where both the load and the deformation applied to the specimen was recorded. Cyclic compression, with an amplitude of 0.3 N corresponding to 1 to 2% compressive strain, was applied to immature bone specimen during a 3-day culture period at an overall loading rate 3–4 cycles/min, in the presence of β-glycerol phosphate and dexamethasone in culture medium. The stress-strain relationship was obtained at the beginning and the end of the culture experiment. In addition, analyses for alkaline phosphate release, cell viability and tissue calcification were also performed. It was exhibited that elastic moduli of bone slices were significantly elevated at the end of the 3-day culture in the presence of cyclic compression, which was a similar phenomenon to significant elevation of the elastic moduli of bone tissue by the maturation from 0-day old to 3-day old. By contrast, no significant changes in the moduli were observed in the absence of cyclic compression or in deactivated, cell-free samples. The increases in the moduli were coincided with the increase in calcified area in the bone samples. It was confirmed that immature bone can respond to compressive loading in vitro and demonstrate the growth of bone matrix, similar to natural, in vivo maturation. The elevation of the elastic moduli was attributable to the increased calcified area and the realignment of collagen fibers parallel to the loading direction. The ex vivo loading system established here can be further applied to study responses to mechanical loading in osteogenesis as well as callus maturation for better understanding of factors to consider in successful bone regeneration with mechanical factors.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bonr.2017.04.002
ISSN
収録物識別子タイプ EISSN
収録物識別子 2352-1872
書誌情報 en : Bone Reports

巻 6, p. 120-128, 発行日 2017-06
著者版フラグ
値 publisher
URI
識別子 https://doi.org/10.1016/j.bonr.2017.04.002
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26877
識別子タイプ HDL
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