@article{oai:nagoya.repo.nii.ac.jp:00024689,
 author = {Kimura, Kana and Itoh, Yoshiyuki and Okada, Tohru and Kubota, Seiji and Kawamura, Mariko and Nakahara, Rie and Oie, Yumi and Kozai, Yuka and Takase, Yuuki and Tsuzuki, Hidenori and Nishio, Naoki and Hiramatsu, Mariko and Fujimoto, Yasushi and Mizutani, Takefumi and Naganawa, Shinji},
 issue = {3},
 journal = {Nagoya Journal of Medical Science},
 month = {Aug},
 note = {The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25–28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11–107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated.},
 pages = {331--338},
 title = {Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas : An initial analysis},
 volume = {79},
 year = {2017}
}