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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

http://hdl.handle.net/2237/26939
http://hdl.handle.net/2237/26939
e28b5ed8-601e-471f-ba31-0f28a922c056
名前 / ファイル ライセンス アクション
article.pdf article.pdf ファイル公開: 2018/05/01 (12.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-09-04
タイトル
タイトル c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling
言語 en
著者 Sekiya, Yoko

× Sekiya, Yoko

WEKO 73371

en Sekiya, Yoko

Search repository
Yamamoto, Eiko

× Yamamoto, Eiko

WEKO 73372

en Yamamoto, Eiko

Search repository
Niimi, Kaoru

× Niimi, Kaoru

WEKO 73373

en Niimi, Kaoru

Search repository
Nishino, Kimihiro

× Nishino, Kimihiro

WEKO 73374

en Nishino, Kimihiro

Search repository
Nakamura, Kenichi

× Nakamura, Kenichi

WEKO 73375

en Nakamura, Kenichi

Search repository
Kotani, Tomomi

× Kotani, Tomomi

WEKO 73376

en Kotani, Tomomi

Search repository
Kajiyama, Hiroaki

× Kajiyama, Hiroaki

WEKO 73377

en Kajiyama, Hiroaki

Search repository
Shibata, Kiyosumi

× Shibata, Kiyosumi

WEKO 73378

en Shibata, Kiyosumi

Search repository
Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 73379

en Kikkawa, Fumitaka

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 ‘This is the peer-reviewed but unedited manuscript version of the following article: [Oncology. v.92, n.5, 2017, p.299-310 (DOI: 10.1159/000458529)]. The final, published version is available at http://www.karger.com/?doi=10.1159/000458529.’
抄録
内容記述 Objective: Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. Methods: We examined the expression of NF-κB family proteins in normal placenta and hydatidiform mole tissues as well as extravillous trophoblast (EVT) and choriocarcinoma cell lines by Western blot and immunohistochemistry. Immunoprecipitation was performed to determine which proteins can bind with c-Rel in choriocarcinoma cells. To investigate the roles of c-Rel in choriocarcinoma, we examined the effects of c-Rel knockdown and overexpression on cell proliferation, migration, and invasion using small interfering RNAs and gene activation plasmid. Results: The expression of c-Rel was strong in choriocarcinoma and EVTs, but very weak in villi of normal placenta and hydatidiform mole. Immunoprecipitation suggested that c-Rel heterodimerizes with p65 in choriocarcinoma. c-Rel knockdown reduced invasion, migration, and AKT phosphorylation in choriocarcinoma cells. c-Rel overexpression in choriocarcinoma increased migratory and invasive abilities, and the effect on invasion was inhibited by a PI3K inhibitor. Conclusion: These findings suggest that c-Rel might play a role in promoting the invasion of choriocarcinoma cells through PI3K/AKT signaling.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Karger
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1159/000458529
ISSN
収録物識別子タイプ PISSN
収録物識別子 0030-2414
書誌情報 en : Oncology

巻 92, 号 5, p. 299-310, 発行日 2017-05
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1159/000458529
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26939
識別子タイプ HDL
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