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Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts
http://hdl.handle.net/2237/26951
http://hdl.handle.net/2237/269518dd10d86-f5a6-439b-952b-21f5edb51722
名前 / ファイル | ライセンス | アクション |
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Takahashi_et_al_RESPNB_2017.pdf ファイル公開:2018/08/01 (896.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-05 | |||||
タイトル | ||||||
タイトル | Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts | |||||
言語 | en | |||||
著者 |
Takahashi, Kota
× Takahashi, Kota× Ito, Satoru× Furuya, Kishio× Asano, Shuichi× Sokabe, Masahiro× Hasegawa, Yoshinori |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ATP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fibroblasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypotonic stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mechanical stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary fibrosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stretch | |||||
抄録 | ||||||
内容記述 | Extracellular adenosine 5′-triphosphate (ATP) acts as an inflammatory mediator of pulmonary fibrosis. We investigated the effects of mechanical and chemical stimuli on ATP release from primary normal human lung fibroblasts. We visualized the ATP release from fibroblasts in real time using a luminescence imaging system while acquiring differential interference contrast cell images with infrared optics. Immediately following a single uniaxial stretch for 1 s, ATP was released from a certain population of cells and spread to surrounding spaces. Hypotonic stress, which causes plasma membrane stretching, also induced the ATP release. Compared with the effects of mechanical stretch, ATP-induced release sites were homogeneously distributed. In contrast to the effects of mechanical stimuli, application of platelet-derived growth factor caused ATP release from small numbers of the cells. Our real-time ATP imaging demonstrates that there is a heterogeneous nature of ATP release from lung fibroblasts in response to mechanical and chemical stimuli. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.resp.2017.04.008 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1569-9048 | |||||
書誌情報 |
en : Respiratory Physiology & Neurobiology 巻 242, p. 96-101, 発行日 2017-08 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | https://doi.org/10.1016/j.resp.2017.04.008 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26951 | |||||
識別子タイプ | HDL |