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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts

http://hdl.handle.net/2237/26951
http://hdl.handle.net/2237/26951
8dd10d86-f5a6-439b-952b-21f5edb51722
名前 / ファイル ライセンス アクション
Takahashi_et_al_RESPNB_2017.pdf Takahashi_et_al_RESPNB_2017.pdf ファイル公開:2018/08/01 (896.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-09-05
タイトル
タイトル Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts
言語 en
著者 Takahashi, Kota

× Takahashi, Kota

WEKO 73391

en Takahashi, Kota

Search repository
Ito, Satoru

× Ito, Satoru

WEKO 73392

en Ito, Satoru

Search repository
Furuya, Kishio

× Furuya, Kishio

WEKO 73393

en Furuya, Kishio

Search repository
Asano, Shuichi

× Asano, Shuichi

WEKO 73394

en Asano, Shuichi

Search repository
Sokabe, Masahiro

× Sokabe, Masahiro

WEKO 73395

en Sokabe, Masahiro

Search repository
Hasegawa, Yoshinori

× Hasegawa, Yoshinori

WEKO 73396

en Hasegawa, Yoshinori

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 ATP
キーワード
主題Scheme Other
主題 Fibroblasts
キーワード
主題Scheme Other
主題 Hypotonic stress
キーワード
主題Scheme Other
主題 Mechanical stress
キーワード
主題Scheme Other
主題 Pulmonary fibrosis
キーワード
主題Scheme Other
主題 Stretch
抄録
内容記述 Extracellular adenosine 5′-triphosphate (ATP) acts as an inflammatory mediator of pulmonary fibrosis. We investigated the effects of mechanical and chemical stimuli on ATP release from primary normal human lung fibroblasts. We visualized the ATP release from fibroblasts in real time using a luminescence imaging system while acquiring differential interference contrast cell images with infrared optics. Immediately following a single uniaxial stretch for 1 s, ATP was released from a certain population of cells and spread to surrounding spaces. Hypotonic stress, which causes plasma membrane stretching, also induced the ATP release. Compared with the effects of mechanical stretch, ATP-induced release sites were homogeneously distributed. In contrast to the effects of mechanical stimuli, application of platelet-derived growth factor caused ATP release from small numbers of the cells. Our real-time ATP imaging demonstrates that there is a heterogeneous nature of ATP release from lung fibroblasts in response to mechanical and chemical stimuli.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.resp.2017.04.008
ISSN
収録物識別子タイプ PISSN
収録物識別子 1569-9048
書誌情報 en : Respiratory Physiology & Neurobiology

巻 242, p. 96-101, 発行日 2017-08
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1016/j.resp.2017.04.008
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26951
識別子タイプ HDL
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