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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein

http://hdl.handle.net/2237/26962
a7c08369-1cf0-436c-a872-6a046e492848
名前 / ファイル ライセンス アクション
nakada2017ProtSci_for_repository.pdf nakada2017ProtSci_for_repository.pdf ファイル公開:2018/06/01 (3.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-09-06
タイトル
タイトル Crystal structure of importin-alpha bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein
著者 Nakada, Ryohei

× Nakada, Ryohei

WEKO 73470

Nakada, Ryohei

Search repository
Matsuura, Yoshiyuki

× Matsuura, Yoshiyuki

WEKO 73471

Matsuura, Yoshiyuki

Search repository
権利
権利情報 "This is the peer reviewed version of the following article: [Nakada, R. and Matsuura, Y. (2017), Crystal structure of importin-α bound to the nuclear localization signal of Epstein-Barr virus EBNA-LP protein. Protein Science, 26: 1231–1235. doi:10.1002/pro.3173], which has been published in final form at [http://doi.org/10.1002/pro.3173]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
抄録
内容記述 Epstein-Barr virus EBNA-LP protein is a transcriptional coactivator of EBNA2. Efficient nuclear localization of EBNA-LP is essential for cooperation with EBNA2. Here, we report the crystal structure of the nuclear import adaptor importin-α1 bound to the nuclear localization signal (NLS) of EBNA-LP that shows EBNA-LP residues 44-RRVRRR-49 binding to the major NLS-binding site at the P0-P5 positions. In contrast to previously characterized classical NLSs that invariably have a basic residue [either lysine (in the vast majority of cases) or arginine] at the P2 position, the EBNA-LP NLS is unique in that it has valine at the P2 position. The loss of the critical P2 lysine (or arginine) is compensated by arginine at the P0 position in the EBNA-LP NLS.
内容記述タイプ Abstract
出版者
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0961-8368
書誌情報 Protein Science

巻 26, 号 6, p. 1231-1235, 発行日 2017-06
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/pro.3173
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26962
識別子タイプ HDL
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