@article{oai:nagoya.repo.nii.ac.jp:00024809,
 author = {Yashima, Akihito and Mizuno, Masashi and Yuzawa, Yukio and Shimada, Koki and Suzuki, Norihiko and Tawada, Hideo and Sato, Waichi and Tsuboi, Naotake and Maruyama, Shoichi and Ito, Yasuhiko and Matsuo, Seiichi and Ohno, Tamio},
 issue = {4},
 journal = {Clinical and Experimental Nephrology},
 month = {Aug},
 note = {Background Malaria is an important tropical disease and has remained a serious health problem in many countries. One of the critical complications of malarial infection is renal injury, such as acute renal failure and chronic glomerulopathy. Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy model in mice infected by murine malaria parasites.　Methods NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium (P.)chabaudi AS and P. yoelii 17X. After the infection, renal pathology and blood and urinary biochemistry were analyzed.Results NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and　increased　proteinuria. These pathological changes were accompanied by deposition of immunoglobulin G and　complement component 3, mainly in the mesangium until　day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal segmental sclerosis according to light　microscopy. In　C57BL/6J mice, renal injuries were not observed from either parasite infection. Conclusion The clinical and pathological features of P.chabaudi AS infection in NC mice might be similar to　quartan malarial nephropathy resulting from human　malaria parasite P. malariae infection. The NC mouse model might therefore be useful in analyzing the underlying　mechanisms and developing therapeutic approaches to　malaria-related nephropathy.},
 pages = {589--596},
 title = {Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice},
 volume = {21},
 year = {2017}
}