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Molecular cloning of chicken TET family genes and role of chicken TET1 in erythropoiesis
http://hdl.handle.net/2237/27080
http://hdl.handle.net/2237/270808e64c7a7-5ff8-493e-8027-19401def7591
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kaneoka.pdf ファイル公開日:2018/08/26 (2.5 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-11-08 | |||||
| タイトル | ||||||
| タイトル | Molecular cloning of chicken TET family genes and role of chicken TET1 in erythropoiesis | |||||
| 言語 | en | |||||
| 著者 |
Yuya, Okuzaki
× Yuya, Okuzaki× Hidenori, Kaneoka× Ken-Ichi, Nishijima× Seitaro, Murakami× Yuki, Ozawa× Shinji, Iijima |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chicken | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ten-eleven translocation (TET) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 5-Hydroxymethylcytosine (5hmC) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-globin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Erythropoiesis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ten-eleven translocation (TET) methylcytosine dioxygenase has potential as an active eraser to regulate the genomic DNA methylation status. We herein cloned chicken TET (cTET) family genes, and confirmed their functions. Quantitative reverse-transcription PCR showed that cTET1 was strongly expressed in erythrocytes throughout development. This cTET1 expression pattern, together with the results of methylated or hydroxymethylated DNA immunoprecipitation, suggests that cTET1 contributes to demethylation around the promoter region of the definitive-type β-globin gene βΑ in erythroid cells. The knockdown of cTET1 in T2ECs chicken erythroid progenitor cells suppressed the induction of βΑ expression under differentiation conditions. These results suggest that cTET1 plays an important role in erythroid cell differentiation. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2017.06.113 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 490, 号 3, p. 753-759, 発行日 2017-08-26 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1016/j.bbrc.2017.06.113 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27080 | |||||
| 識別子タイプ | HDL | |||||
