{"created":"2021-03-01T06:32:53.315172+00:00","id":24897,"links":{},"metadata":{"_buckets":{"deposit":"c0d6d0fb-4f32-4f6f-aa0f-1c6af7a33c48"},"_deposit":{"created_by":17,"id":"24897","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"24897"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00024897","sets":["499:508:509:2043"]},"author_link":["74127","74128","74129","74130","74131"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"486","bibliographicPageStart":"477","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Indoxyl sulfate (IS) induces fibrosis and inflammation in kidneys via oxidative stress through the induction of transforming growth factor-β1 (TGF-β1) and monocyte chemotactic protein-1 (MCP-1). Furthermore, IS is a potent endogenous agonist for aryl hydrocarbon receptor (AHR), which regulates the transcription of genes such as cytochrome P450 (CYP) 1A1. Indole-3-propionic acid (IPA) is an antioxidant and has been reported to be neuroprotective. We determined whether IPA suppresses IS-induced expression of AHR, CYP1A1, TGF-β1, and MCP-1 in proximal tubular cells. The effects of IS on the expression of AHR, CYP1A1, TGF-β1, and MCP-1 were studied using normotensive rats and hypertensive rats. The effects of IPA on IS-induced expression of AHR, CYP1A1, TGF-β1, and MCP-1 were studied using proximal tubular cells (HK-2). Furthermore, the effects of IPA on IS-induced expression and phosphorylation of signal transducer and activator of transcription 3 (Stat3) were studied in HK-2 cells. Administration of IS induced the expression of AHR, CYP1A1, TGF-β1, and MCP-1 in the tubular cells of rat kidneys. IPA significantly suppressed IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-β1, and MCP-1 in HK-2 cells. IPA suppressed the IS-induced expression and phosphorylation of Stat3 in HK-2 cells. Furthermore, knockdown of Stat3 inhibited the IS-induced mRNA and protein expression of AHR, CYP1A1, TGF-β1, and MCP-1 in HK-2 cells. In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-β1, and MCP-1 through suppression of Stat3 in proximal tubular cells. Thus, IPA suppresses IS-induced expression of fibrotic and inflammatory genes in proximal tubular cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This study was supported in part by JSPS research grant (JSPS KAKENHI Grant Number 15J00397).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/27117"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.79.4.477","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University Graduate School of Medicine, School of Medicine","subitem_publisher_language":"en"}]},"item_9_relation_43":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/794.html","subitem_relation_type_select":"URI"}}]},"item_9_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yisireyili, Maimaiti","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshita, Kyosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74129","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murohara, Toyoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"74131","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-22"}],"displaytype":"detail","filename":"07_Yisireyli.pdf","filesize":[{"value":"11.5 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"07_Yisireyli.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/24897/files/07_Yisireyli.pdf"},"version_id":"f05d0f1d-4ae2-491d-b73e-c5293752a789"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"indole-3-propionic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"indoxyl sulfate","subitem_subject_scheme":"Other"},{"subitem_subject":"aryl hydrocarbon receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β1","subitem_subject_scheme":"Other"},{"subitem_subject":"proximal tubular cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["2043"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-22"},"publish_date":"2017-11-22","publish_status":"0","recid":"24897","relation_version_is_last":true,"title":["Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T04:17:46.581033+00:00"}