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FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer
http://hdl.handle.net/2237/27148
http://hdl.handle.net/2237/271485ff2a700-ac45-4fbd-a30c-2f3d3b67a09a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ANNALS_OF_SURGICAL_ONCOLOGY_24_11_3438-3445.pdf ファイル公開：2018/10/21 (742.9 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-12-07 | |||||
| タイトル | ||||||
| タイトル | FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer | |||||
| 言語 | en | |||||
| 著者 |
Tanaka, Haruyoshi
× Tanaka, Haruyoshi× Kanda, Mitsuro× Shimizu, Dai× Tanaka, Chie× Kobayashi, Daisuke× Hayashi, Masamichi× Iwata, Naoki× Yamada, Suguru× Fujii, Tsutomu× Nakayama, Goro× Sugimoto, Hiroyuki× Fujiwara, Michitaka× Niwa, Yukiko× Kodera, Yasuhiro |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at Springer via https://doi.org/10.1245/s10434-016-5636-y | |||||
| 言語 | en | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Gastric cancer (GC) relapse can occur even if curative resection is achieved. Biomarkers predicting recurrence are needed to provide appropriate postoperative surveillance and perioperative therapeutic strategy. Methods: A global expression profiling was performed using tissues from GC patients with synchronous liver-confined metastasis. Family with sequence similarity 46, member C (FAM46C), was identified as a candidate biomarker. mRNA expression analysis, direct nucleotide sequencing, bisulfite sequencing and copy number assays for FAM46C were performed with eleven GC cell lines. Expression levels of FAM46C in primary GC tissues from 129 patients who underwent curative GC resection were determined and correlated with clinicopathological factors, including postoperative outcome. Results: Levels of FAM46C mRNA differed among GC cell lines. Point mutations in FAM46C were detected in five GC cell lines accompanied with reduced FAM46C transcription. No hypermethylation was found in the promoter region of FAM46C. Copy number alterations were found in six GC cell lines with differing FAM46C transcription levels. Reduced FAM46C mRNA expression levels were detected in 117 (91 %) GC specimens compared with adjacent noncancerous tissues. Low FAM46C expression levels were significantly associated with larger macroscopic GC tumor sizes. The low FAM46C expression group was likely to have shorter disease-free survival than the high group and low FAM46C level was identified as an independent risk factor for recurrence after curative resection. FAM46C expression levels were low in all cases that were later found to have hepatic recurrence. Conclusions: Reduced GC expression of FAM46C is a potential biomarker to predict hepatic recurrence after curative gastrectomy. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
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| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1245/s10434-016-5636-y | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1068-9265 | |||||
| 書誌情報 |
en : Annals of Surgical Oncology 巻 24, 号 11, p. 3438-3445, 発行日 2017-10-21 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | https://doi.org/10.1245/s10434-016-5636-y | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27148 | |||||
| 識別子タイプ | HDL | |||||
