@article{oai:nagoya.repo.nii.ac.jp:00024928,
 author = {Nakazaki, Atsuo and Hashimoto, Keiko and Ikeda, Ai and Shibata, Takahiro and Nishikawa, Toshio},
 issue = {17},
 journal = {The Journal of Organic Chemistry},
 month = {Sep},
 note = {De novo synthesis of possible candidates for the Inagami–Tamura endogenous digitalis-like factor (EDLF) was achieved to validate a previously proposed structure. Our synthetic approach involves a highly regio- and diastereoselective Mizoroki–Heck reaction and a Friedel–Crafts-type cyclodehydration to construct steroidal tetracycle 14 as a versatile common intermediate leading to seven 2,14β-dihydroxyestradiol analogues 1a–c, 2a–c, and 3 as possible candidates. By comparing the potency of inhibitory activity against Na+/K+-ATPase between the synthesized candidates and the EDLF, it was found that the proposed structure is not likely to be a true structure of the Inagami–Tamura EDLF.},
 pages = {9097--9111},
 title = {De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor},
 volume = {82},
 year = {2017}
}